2012 Fiscal Year Final Research Report
Development of new HPV vaccine for prevention of cervical cancer
| Project/Area Number |
22390309
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Kouji 筑波大学, 医学医療系, 准教授 (30302714)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 子宮頸癌 / ワクチン / HPV / L2 / VLP |
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| Research Abstract |
Development of specific neutralizing antibodies following natural HPV 16 infection did not favor a better outcome of low-grade cervical lesions induced by HPV 16. There are at least two cross-neutralization epitopes in the region from aa56 to aa75 and an antigen capable of presenting the two cross-neutralization epitopes would be a good vaccine candidate for a broad-spectrum of high-risk HPVs.
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[Journal Article] HLA Class II DRB1*1302 1 allele protects against progression to cervical intraepithelial neoplasia grade 3:A multicenter, prospective, cohort study.2012
Author(s)
Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, Hirata R, Mitsuhashi A, Fujii T, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
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Journal Title
Int J Gynecol Cancer
Volume: 22(3)
Pages: 471-478
DOI
Peer Reviewed
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[Journal Article] Do neutralizing antibody responses generated by human papillomavirus infections favor a better outcome of low-grade cervical lesions?2012
Author(s)
Ochi H, Matsumoto K, Kondo K, Oki A, Furuta R, Hirai Y, Yasugi T, Takatsuka N, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Kanda T, Yoshikawa H
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Journal Title
J Med Virol
Volume: 84(7)
Pages: 1128-1134
DOI
Peer Reviewed
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[Journal Article] Guidelines for office gynecology in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2011 edition.2012
Author(s)
Takeda T, Wong TF, Adachi T, Ito K, Uehara S, Kanaoka Y, Kamada M, Kitagawa H, Koseki S, Gomibuchi H, Saito J, Shirasu K, Sueoka K, Sugimoto M, Suzuki M, Sumi T, Takeda S, Tasaka K, Noguchi Y, Fujii S, Fujii T, Fujiwara M, Maeda T, Matsumoto K, Momoeda M
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Journal Title
J Obstet Gynaecol Res
Volume: 38(4)
Pages: 615-631
DOI
Peer Reviewed
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[Journal Article] Subsequent risks for cervical precancer and cancer in women with low-grade squamous intraepithelial lesions unconfirmed by colposcopy-directed biopsy: results from a multicenter, prospective, cohort study2012
Author(s)
Matsumoto K, Hirai Y, Furuta R, Takatsuka N, Oki A, Yasugi T, Maeda H, Mitsuhashi A, Fujii T, Kawana K, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, Yoshikawa H
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Journal Title
Int J Clin Oncol
Volume: 17(3)
Pages: 233-239
DOI
Peer Reviewed
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[Journal Article] Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study.
Author(s)
Fujii T, Takatsuka N, Nagata C, Matsumoto K, Oki A, Furuta R, Maeda H, Yasugi T, Kawana K, Mitsuhashi A, Hirai Y, Iwasaka T, Yaegashi N, Watanabe Y, Nagai Y, Kitagawa T, and Yoshikawa H.
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Journal Title
Int J Clin Oncol
Volume: (in press)
Peer Reviewed
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[Journal Article] Incidence of venous thromboembolism before treatment in cervical cancer and the impact of management on venous thromboembolism after commencement of treatment
Author(s)
Satoh T, Matsumoto K, Tanaka YO, Akiyama A, Nakao S, Sakurai M, Ochi H, Onuki M, Minaguchi T, Sakurai H, Yoshikawa H
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Journal Title
Thrombosis Research
Volume: (in press)
DOI
Peer Reviewed
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[Presentation] Does paclitaxel plus carboplatin (TC) substitute for paclitaxel plus cisplatin (TP) in cervical cancer without prior platinum treatment2012
Author(s)
Tanabe H,Kitagawa R,Shibata T,Saito M,Okamoto A,Takakura S,Sasaki H,Ochiai K,Yoshikawa H,Kamura T
Organizer
The 37th ESMO
Place of Presentation
Vienna,Austria
Year and Date
20120928-1002
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