2012 Fiscal Year Final Research Report
Basic and clinical research for surgical treatment of unilaterallaryngeal paralysis aiming at reinnervation of the laryngeal muscle
| Project/Area Number |
22390316
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kumamoto University |
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Principal Investigator |
YUMOTO Eiji 熊本大学, 生命科学研究部, 教授 (40116992)
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| Co-Investigator(Renkei-kenkyūsha) |
SANUKI Tetsuji 熊本大学, 医学部附属病院, 講師 (10335896)
KUMAI Yoshihiko 熊本大学, 生命科学研究部, 助教 (00555774)
MIYAMARU Satoru 熊本大学, 医学部附属病院, 助教 (10535636)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳・神経 / 喉頭麻痺 / 反回神経 / 神経再支配 / 神経筋弁 |
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| Research Abstract |
The nerve-muscle pedicle (NMP) flap implantation immediately aftertransection of the recurrent laryngeal nerve facilitated reinnervation of the denervatedthyroarytenoid muscle. Further, NMP implantation was effective in the recovery fromatrophic changes in long-term denervated thyroarytenoid muscle. The authors performedarytenoid adduction in 10 patients and NMP flap implantation combined with arytenoidadduction in 32 patients during research period. The latter patient group showedtime-dependent improvement of vocal function and most of them retrieved their own voicesbefore the onset of laryngeal paralysis.
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