2012 Fiscal Year Final Research Report
Elucidation ofpathogenesis and establishment of objective assessment for intraocular pressure-dependent optic nerve damage
| Project/Area Number |
22390324
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
NEGI Akira 神戸大学, 大学院・医学研究科, 教授 (00189359)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Makoto 神戸大学, 大学院・医学研究科, 講師 (80273788)
YAMADA Yuko 神戸大学, 大学院・医学研究科, 助教 (00359861)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 緑内障 / 視神経症 / 眼圧 / 網膜神経節細胞 / 多局所視覚誘発電位 / 光干渉断層計 / 一次視覚野 / グリア細胞 |
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| Research Abstract |
The degree of visual field defect in glaucomatous patients correlated with postural fluctuation of intraocular pressure. Optimal conditions for multi-channel, multifocal visual evoked potential (mfVEP) recordings were established. Visual dysfunction in glaucomatous damages was objectively detected by quantitative analysis of mfVEP global index we have developed. We found that astrocytes in the optic nerve and retinal ganglion cells express aquaporin 9 water channel and that glaucoma and optic nerve crush injuries decrease it.
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