Research and Development of Emergency Life Support System

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390336
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: The University of Tokyo
• Principal Investigator: ISOYAMA Takashi 東京大学, 大学院・医学系研究科, 講師 (20302789)
• Co-Investigator(Renkei-kenkyūsha): SAITO Itsuro 東京大学, 大学院・医学系研究科, 特任研究員 (80334225) ; ABE Yusuke 東京大学, 大学院・医学系研究科, 准教授 (90193010) ; BABA Atsushi 芝浦工業大学, システム工学部, 教授 (50392444) ; FUKUNAGA Kazuyoshi 杏林大学, 保健学部, 准教授 (30366405)
• Project Period (FY): 2010 – 2012
• Keywords: 救急蘇生学

Research Abstract

A new blood pump for next generation Percutaneous Cardio-Pulmonary Support (PCPS) system and a novel surface coating method for silicone membrane hollow fiber by physical adsorption were developed. The new blood pump named Troidal Convolution Pump (TCP) is based on the principle of cascade pump, and perfused 5 L/min and 350 mmHg at 2450 rpm. The blood is given static pressure by the multiple centrifugal forces during spiral turning in the pump room. The inlet of the blood pump is located on the side wall of the pump housing. There are two semicircular blood pump rooms to keep equilibrium in the axis symmetry. There are two pump outlets located at the top surface of the pump in the axial direction to perfuse the blood to the oxygenator. The impeller is suspended by a monopivot bearing for long-term use and driven by magnet coupling using permanent magnets. The impeller consisted of 20 vanes, and its diameter was 66 mm. The authors employed a dense silicone membrane hollow fiber in this study because of its no-plasma-leakage nature. Additionally, newly developed hydrophilic and biocompatible phosphorylcholine surface coated silicone hollow fiber demonstrated low protein adsorption. The relative intensity of protein adsorption using newly developed hydrophilic phosphorylcholine surface was 7.2 % of non-coated surface. The hollowfiber with no plasma leakage contributes to the next-generation portable, preprimed, and long-termsupport ECLS.

Research Products

• [Journal Article] Development of Normal-S uction Boundary Control Method Based on Inflow Cannula PressureWaveform for the Undulation Pump Ventricular Assist Device (2012)
  • Author(s): Kohei Ishii, Itsuro Saito, Takashi Isoyam a, Hidemoto Nakagawa, Nakano Emiko, Toshiya Ono, Wei Shi, Yusuke Inoue, an d Yusuke Abe
  • Journal Title: Artificial Organs Volume: 36(9) Pages: 812-816
  • DOI: doi:10.1111/j.1525-1594.2012.01451.x
  • Peer Reviewed
• [Journal Article] The helical flow pump with a hydrodynamic levitation impeller (2012)
  • Author(s): Abe Y, Ishii K, Isoyama T, Saito I, Inou e Y, Ono T, Nakagawa H, Nakano E, Fu kazawa K, Ishihara K, Fukunaga K, On o M, Imachi K
  • Journal Title: J Artif Organs Volume: 15 Pages: 331-340
  • DOI: DOI:10.1007/s10047-012-0659-z
  • Peer Reviewed
• [Journal Article] Oxygen ation to Bovine Blood in Artificial Heart and Lung Using Vibrating Flow Pump: Experiment and Numerical Analysis Bas ed on Non-Newtonian Model (2010)
  • Author(s): Shintaku H, Yonemura T, Tsuru K, Isoy ama T, Yambe T, and Kwano S
  • Journal Title: Journal of fluid science and technology Volume: 5(2) Pages: 1125-1131
  • Peer Reviewed
• [Presentation] プレプライミング人工肺を目指した緊急生命維持システムの研究開発 (2012)
  • Author(s): 磯山隆、根本功、斎藤逸郎、有吉洸希、石井耕平、井上雄介、福長一義、井街宏、阿部裕輔
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡(アクロス福岡)
  • Year and Date: 2012-11-23
• [Presentation] ELSS用血液ポンプの開発 (2012)
  • Author(s): 有吉洸希,磯山隆,石井耕平,小野俊哉,井上雄介,斎藤逸郎,中川英元,阿部裕輔
  • Organizer: 第40回人工心臓と補助循環懇話会
  • Place of Presentation: 大分(クアージュゆふいん)
  • Year and Date: 2012-02-18
• [Presentation] プレプライミング人工肺を目指した滅菌法の基礎的研究 (2011)
  • Author(s): 磯山隆、根本功、斉藤逸郎、福長一義、井上雄介、石井耕平、有吉洸希、井街宏、阿部裕輔
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京(日本都市センターホテル)
  • Year and Date: 2011-11-26
• [Presentation] Portableheart-lungmachine新時代の到来 (2010)
  • Author(s): 磯山隆、根本功、斎藤逸郎、福長一義、矢野哲也、井上雄介、石井耕平、井街宏、阿部裕輔
  • Organizer: 日本人工臓器学会第48回大会
  • Place of Presentation: 仙台(仙台国際センター)
  • Year and Date: 2010-11-19
• [Presentation] Development of a ToroidalConvolution Pump for Emergency Life Support System (2010)
  • Author(s): Saito I, Nemoto I, Isoyama T, Ono T, Nakagawa H, Shi W, Inoue Y, Ishii K, and Abe Y
  • Organizer: European Society for Artificial Organs
  • Place of Presentation: Skopje, R. Macedonia
  • Year and Date: 2010-09-09
• [Presentation] 救急救命システム用の血液ポンプの開発 (2010)
  • Author(s): 斎藤逸郎、根本功、磯山隆、河野明正、小野俊哉、中川英元、時偉、井上雄介、石井耕平、阿部裕輔
  • Organizer: 日本生体医工学会第49回大会
  • Place of Presentation: 大阪(大阪国際交流センター)
  • Year and Date: 2010-06-25
• [Remarks]
  • URL: http://www.bme.gr.jp