2013 Fiscal Year Final Research Report
The development of cell transplantation therapy against sepsis-associated multiple organ dysfunction targeted at endogenous stem cell function.
| Project/Area Number |
22390338
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZU Takeshi 大阪大学, 大学院医学系研究科, 教授 (50196474)
KUWAGATA Yasuyuki 大阪大学, 大学院医学系研究科, 招へい教授 (50273678)
SHIOZAKI Tadahiko 大阪大学, 大学院医学系研究科, 助教 (60278687)
OGURA Hiroshi 大阪大学, 大学院医学系研究科, 准教授 (70301265)
TASAKI Osamu 長崎大学, 大学病院, 教授 (90346221)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 細胞移植治療 / 骨髄間質細胞 / 骨髄由来単核球細胞 / 幹細胞 / 敗血症 / クラッシュ症候群 / 血管内皮細胞 / 脈絡叢上皮細胞 |
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| Research Abstract |
The intravenous cell transplantation using bone marrow stromal cells or bone marrow-derived mononuclear cells suppressed systemic inflammatory response, reduced multiple organ injuries and improved mortality rate against the animal model of critical illness. Sepsis induced in rodents altered the expression of gene to regulate stem cell function in the each organ. When endothelial cells or choroid plexus epithelial cells were co-cultured with bone marrow stromal cells, the factors to enhance stem cell function were up-regulated at the transcriptional level in their cells. Cell transplantation therapy is a promising modality to activate endogenous stem cells and to protect and regenerate injured organs in the treatment of critical illness.
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Research Products
(10 results)
