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2012 Fiscal Year Final Research Report

CLEC2-PLAG complex-induced oncogenic transformation in the intra-lymphatic microenvironment

Research Project

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Project/Area Number 22390345
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionFukuoka Dental College

Principal Investigator

SAWA Yoshihiko  福岡歯科大学, 歯学部, 教授 (70271666)

Co-Investigator(Kenkyū-buntansha) KATO Yukinari  東北大学, 医学部, 教授 (00571811)
TANIGUCHI Kunihisa  福岡歯科大学, 歯学部, 教授 (90105685)
TSURUGA Eichi  福岡歯科大学, 歯学部, 教授 (30295901)
KAJIYA Hiroshi  福岡歯科大学, 歯学部, 講師 (80177378)
HATAKEYAMA Yuji  福岡歯科大学, 歯学部, 講師 (40302161)
OKA Kyoko  福岡歯科大学, 歯学部, 講師 (60452778)
Project Period (FY) 2010 – 2012
Keywords口腔解剖学(含組織学発生学) / 微小循環
Research Abstract

We developed novel antibodies specific for human and mouse podoplanin (PMab-1,NZ-1.2) sold in MBL, Imgenex, Sigma, and Millipore. Immunohistochemical studies on the oral squamous cell carcinoma (SCC) revealed that platelets exist between SCC and lymphatic endothelial cells at the luminal side of lymphatic vessels where SCC attached. The platelets may contribute to the lymphogenous metastasis of SCC. The adhesion activity to human lymphatic endothelial cells was higher in podoplanin-positive SCC than in podoplanin-negative SCC, and the adhesion of SCC was blocked by NZ-1.2. Anti-podoplanin may be useful for the inhibition of the lymphogenous metastasis of SCC.

  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (22 results) Book (2 results)

  • [Journal Article] Risk factors to cause tooth formation anomalies in chemotherapy of paediatric cancers.2013

    • Author(s)
      Nishimura S, Sawa Y.
    • Journal Title

      Eur J Cancer Care

      Volume: 22 Pages: 353-360

  • [Journal Article] Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.2013

    • Author(s)
      Takata S, Sawa Y
    • Journal Title

      Acta Histochem Cytochem

      Volume: 46 Pages: 35-42

  • [Journal Article] Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice2013

    • Author(s)
      Uchiyama , Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 46 Pages: 97-104

  • [Journal Article] The expression of podoplanin and classic cadherins in the mouse brain.2012

    • Author(s)
      Kaji C, Kato Y, Sawa Y.
    • Journal Title

      J Anat

      Volume: 220 Pages: 435-446

  • [Journal Article] Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmentedciliary epithelial cells in vitro.2012

    • Author(s)
      Yamanouchi K, Tsuruga E, Oka K, Sawa Y
    • Journal Title

      Connect Tissue Res

      Volume: 53 Pages: 14-20

  • [Journal Article] Intracellular interaction of EMILIN-1 with fibrillin-1 in human periodontal ligament cells2012

    • Author(s)
      Nakatomi Y, Tsuruga E, Sawa Y
    • Journal Title

      Orthodontic Waves

      Volume: 71 Pages: 66-69

  • [Journal Article] Latent transforming growth factor-b binding protein 2 negatively regulates coalescence of oxytalan fibers induced by stretching stress.2012

    • Author(s)
      Tsuruga E, Oka K, Hatakeyama Y, Sawa Y.
    • Journal Title

      Connect Tiss Res

      Volume: 53 Pages: 521-527

  • [Journal Article] Immunohistochemical examination of novel rat monoclonal antibodies against mouse and human podoplanin.2012

    • Author(s)
      Kaji C, Tsujimoto Y, Kaneko, MK, Kato Y and Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 45 Pages: 227-237

  • [Journal Article] A chimeric anti-podoplanin antibody suppresses tumor metastasis via neutralization and antibody-dependent cellular cytotoxicity.2012

    • Author(s)
      Kaneko MK, Sawa Y, Kato Y.
    • Journal Title

      Cancer Sci

      Volume: 103 Pages: 1913-1919

  • [Journal Article] Roles of collagen and periostin expression by cranial neural crest cells during soft palate development.2012

    • Author(s)
      Oka K, Tsuruga T, Hatakeyama Y, Sawa Y.
    • Journal Title

      J Histochem Cytochem

      Volume: 60 Pages: 57-68

  • [Journal Article] Cellular turnover in epithelial rests of Malassez in the periodontal ligament of the mouse molar.2012

    • Author(s)
      Oka K, Sawa Y
    • Journal Title

      Eur J Oral Sci

      Volume: 120 Pages: 484-494

  • [Journal Article] EMILIN-1 regulates the amount of oxytalan fiber formation in periodontal ligaments in vitro.2011

    • Author(s)
      Nakatomi Y, Tsuruga E, Sawa Y.
    • Journal Title

      Connect Tissue Res

      Volume: 52 Pages: 30-35

  • [Journal Article] Stretch stimuli increase fibulin-5/EMILIN-1 complex on oxytalan fibers in human periodontal ligament cells.2011

    • Author(s)
      Nakashima K, Tsuruga E, Sawa Y.
    • Journal Title

      Orthodontic Waves

      Volume: 70 Pages: 15-20

  • [Journal Article] Establishment of a novel monoclonal antibody SMab-1specific for IDH1-R132S mutation.2011

    • Author(s)
      Kaneko MK, Sawa Y, Kato Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 406 Pages: 608-613

  • [Journal Article] The effect of valproic acid on mesenchymal pluripotent cell proliferation and differentiation in extracellular matrices.2011

    • Author(s)
      Hatakeyama Y, Oka K, Tsuruga E, T, Sawa Y.
    • Journal Title

      Drug Target Insights

      Volume: 5 Pages: 1-9

  • [Journal Article] Immunohistochemical and Immunocytochemical Localization of Amylase in Rat Parotid Glands and von Ebner's Glands by Ion Etching-Immunoscanning Electron Microscopy2011

    • Author(s)
      Yahiro J, Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 44 Pages: 201-212

  • [Journal Article] Expression of podoplanin and classical cadherins in salivary gland epithelial cells of klotho- deficient mice2011

    • Author(s)
      Amano I, Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 44 Pages: 267-276

  • [Journal Article] Growth Differentiation Factor 5 induces matrix metalloproteinase 2 expression in periodontal ligament cells and modulates MMP-2 and MMP-13 activity in osteoblasts.2011

    • Author(s)
      Hatakeyama Y,Oka K,Tsuruga E,Sawa Y.
    • Journal Title

      Bone and Tissue Regeneration Insights

      Volume: 4 Pages: 1-10

  • [Journal Article] Immunohistochemical examination on the distribution of cells expressed lymphatic endotheial marker podoplanin and LYVE-1 in the mouse tongue tissue.2010

    • Author(s)
      Noda Y, Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 43 Pages: 61-68

  • [Journal Article] The effect of valproic acid onmicroscopic study of podoplanin localization in mouse salivary gland myoepithelium.2010

    • Author(s)
      Hata,Tsuruga E,Sawa Y. ImmunoelectronSawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 43 Pages: 77-82

  • [Journal Article] Immunohistochemical examination for the distribution of podoplanin-expressing cells in developing mouse molar tooth germs.2010

    • Author(s)
      Imaizumi Y, Tsuruga E, Sawa Y.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 43 Pages: 115-121

  • [Journal Article] Fibulin-4, and -5, but not Fibulin-2, are associated with tropoelastin deposition in elastin- producin cell culture.2010

    • Author(s)
      Yamauchi Y, Tsuruga E, Sawa Y.Ishikawa H.
    • Journal Title

      Acta Histochem Cytochem

      Volume: 43 Pages: 131-138

  • [Book] 臨床免疫・アレルギー サイトカインのすべて

    • Author(s)
      沢
    • Total Pages
      292-295
    • Publisher
      科学評論社
  • [Book] ネッター頭頸部・口腔顎顔面の臨床解剖アトラス

    • Author(s)
      沢
    • Total Pages
      399-492
    • Publisher
      医歯薬出版社

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Published: 2014-08-29  

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