2013 Fiscal Year Final Research Report
Development of a new treatment for trigeminal neuron sensitization
| Project/Area Number |
22390365
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthetic dentistry
|
|---|
| Research Institution | The University of Tokushima (2012-2013)
Okayama University (2010-2011) |
|---|
Principal Investigator |
MATSUKA Yoshizo 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90243477)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
YAMAMOTO Yumiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403496)
KUMADA Ai 岡山大学, 岡山大学病院, 医員 (40610895)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OGUMA Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00002262)
|
|---|
| Project Period (FY) |
2010-04-01 – 2014-03-31
|
| Keywords | 三叉神経障害性疼痛モデル / 神経節細胞 / 疼痛行動 / 知覚神経節 / A型ボツリヌス毒素 / 遊離 / 神経内走行 |
|---|
| Research Abstract |
Fluorescein labeled botulinum toxin heavy chain which works for endocytosis was injected into rat face skin and found in ipsilateral trigeminal ganglion. The labeled botulinum toxin heavy chain was not found on the contralateral side or in the only fluorescein injection. The uptake was inhibited by colchicine treatment, which blocks axonal transport. Intradermal injection of botulinum toxin alleviates infraorbital nerve constriction induced thermal hyperalgesia in an operant assay. Direct application of botulinum toxin to dorsal root ganglia reversed the sciatic nerve entrapment induced decreases in withdrawal thresholds.
|
-
-
-
[Journal Article] Intradermal injection of Botulinum toxin type A alleviates infraorbital nerve constriction-induced thermal hyperalgesia in an operant assay2012
Author(s)
Kumada A, Matsuka Y, Spigelman I, Maruhama K, Yamamoto Y, Neubert JK, Noland TA, Watanabe K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
-
Journal Title
Journal of Oral Rehabilitation
Volume: 39
Pages: 63-72
DOI
Peer Reviewed
-
[Journal Article] Guidelines and recommendations for assessment of somatosensory function in orofacial pain conditions - a taskforce report2011
Author(s)
Svensson P, Baad-Hansen L, Pigg M, List T, Eliav E, Ettlin D, Michelotti A, Tsukiyama Y, Matsuka Y, Jääskeläinen SK, Essick G, Greenspan JD, Drangsholt M.
-
Journal Title
Journal of Oral Rehabilitation
Volume: 38
Pages: 366-394
DOI
Peer Reviewed
-
-
[Journal Article] Peripheral administration of Botulinum toxin type A decreases exaggerated neurotransmitter release and reverses neuropathy-induced gene expression changes in trigeminal ganglia2010
Author(s)
Kumada A, Matsuka Y, Kitamura Y, Spigelman I, Ishihara Y, Yamamoto Y, Hikasa T, Sonoyama W, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
URL
Peer Reviewed
-
-
-
-
-
[Presentation] Botulinum toxin endocytosis into trigeminal neurons alleviates neuropathic pain2013
Author(s)
Maruhama K, Matsuka Y, Yamamoto Y, Terayama R, Komi K, Ono M, Maekawa K, Kamioka H, Yamashiro T, Sugimoto T, Matsushita O, Kuboki T.
Organizer
International Association for Dental Research
Place of Presentation
(アメリカ)ワシントン州コンベンションセンター
Year and Date
2013-03-22
-
-
[Presentation] 神経毒素成分を精製したA型ボツリヌス毒素の三叉神経への取り込みと輸送2012
Author(s)
丸濵功太郎, 松香芳三, 山本由弥子, 寺山隆司, 古味佳子, 大野充昭, 前川賢治, 上岡 寛, 山城 隆, 杉本朋貞, 松下治, 小熊恵二, 窪木拓男
Organizer
日本口腔顔面痛学会
Place of Presentation
(東京都)慶應義塾大学
Year and Date
2012-11-03
-
-
[Presentation] Botulinum neurotoxin type A endocytosis into trigeminal neurons and its effect on neuropathic pain behavior2011
Author(s)
Maruhama K, Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Suzuki T, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
Organizer
Society for Neuroscience
Place of Presentation
(アメリカ)ワシントン州コンベンションセンター
Year and Date
2011-11-15
-
-
[Presentation] Botulinum toxin type A neurotoxin endocytosis into trigeminal neuron and its effect onto neuropathic pain beahavior2011
Author(s)
Kumada A, Matsuka Y, Yamamoto Y, Suzuki T, Spigelman I, Neubert JK, Nolan TA, Watanabe K, Maruhama K, Maekawa K, Kamioka H, Yamashiro T, Kuboki T, Oguma K.
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
(北海道)札幌コンベンションセンター
Year and Date
2011-09-07
-
-
-
[Presentation] Pepripehral administration of Botlinum toxin type A neurotoxin reverses trigeminal thermal hyperalgesia2010
Author(s)
Kumada A, Matsuka Y, Spigelman I, Neubert JK, Nolan TA, Yamamoto Y, Sato K, Watanabe K, Yamamoto K, Murakami K, Kuboki T, Oguma K.
Organizer
Asian Academy of Craniomandibular Disorders
Place of Presentation
(福岡県)九州大学
Year and Date
2010-10-03
-
