2012 Fiscal Year Final Research Report
Cancer-targeted liposome coupled to viral proteins for imaging cancer cells
| Project/Area Number |
22390380
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
UZAWA Katsuhiro 千葉大学, 大学院・医学研究院, 准教授 (30302558)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Kengo 千葉大学, 大学院・医学研究院, 助教 (70451755)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床腫瘍学 / リポソーム / シンドビスウイルス |
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| Research Abstract |
We developed a novel cancer-targeted liposome coupled to sindbis virus proteins (SIN liposome) on the surface that can be used for imaging tumors and an intra-operative navigation system. The imaging efficacy of this liposome was assessed in a nude mouse bearing a tumor using a clinical CT. CT imaging showed that CT signal increases were detected in tumor site treated with SIN liposomes. Thus, this finding that SIN liposomes selectively fused with a tumor suggested the application of this cancer-targeted liposome to cancer imaging.
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Research Products
(5 results)
