2012 Fiscal Year Final Research Report
Personalized immunochemotherapy for oral cancer basedon the genetic diagnosis
| Project/Area Number |
22390386
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIRO Koichi 愛媛大学, 大学院・医学系研究科, 准教授 (90314880)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Masato 慶應大学, 医学部, 特任准教授 (10243718)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 口腔癌 / 癌免疫療法 / 癌抗原 / OK-432 |
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| Research Abstract |
Recently immunotherapy is a promising cancer therapy. And Dendritic cells (DC)-based vaccination is widely tested as a promising therapeutic cancer vaccine in multiple clinical trials. But there is no utility cancer antigen for oral cancer. We have identified Mucin 1 as a critical cancer antigen in oral cancer. Furthermore we conducted the in vitro experiments to examine whether or not chemotherapeutic drugs which are used for patients with oral cancer, may enhance T cell-stimulating ability of DCsvia regulation of the expression of PD-Ls. And then we identified IL-6, IL-8 and GCSFas a prognosis biomarker of oral cancer patients. The findings obtained from this study lead to development of personalized immunochemotherapy for oral cancer patients.
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[Journal Article] Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes.2013
Author(s)
Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Mitobe J, Matsudaira H, Nagatsuma K, Uchiyama K, Kajihara M, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Prognostic impact of expression of bcl-2 and bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M,Fujita T, Kawakami Y, Hamakawa H.
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Journal Title
Neoplasia
Volume: 15(3)
Pages: 305-14
Peer Reviewed
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[Journal Article] Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo2012
Author(s)
Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in patients with advanced pancreatic carcinoma.2012
Author(s)
Kimura Y, Tsukada J, Tomoda T, Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Increased telomerase activity and hTERT expression in human salivary gland carcinomas2011
Author(s)
Shigeishi H, Sugiyama M, Tahara H, Ono S, Kumar Bhawal U, Okura M, Kogo M, Shinohara M, Shindoh M, Shintani S, Hamakawa H, Takata T, Kamata N.
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Journal Title
Oncol Lett 1
Volume: 2(5)
Pages: 845-850
Peer Reviewed
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[Journal Article] Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo.2010
Author(s)
Sasaki T, Nakashiro K, Tanaka H, Azuma K, Goda H, Hara S, Onodera J, Fujimoto I, Tanji N, Yokoyama M, Hamakawa H
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Journal Title
Biochem Biophys Res Commun 13
Volume: 399(1)
Pages: 79-83
Peer Reviewed
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