2012 Fiscal Year Final Research Report
Effect of dental-plaque eco-system to caries-related genes in cariogenic mutans streptococci
| Project/Area Number |
22390391
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOZAI Katsuyuki 広島大学, 大学院・医歯薬保健学研究院, 教授 (10178212)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Go 広島大学, 大学院・医歯薬学総合研究科, 助教 (50403530)
HAYASHI Fumiko 広島大学, 大学院・医歯薬学総合研究科, 助教 (50325180)
MITSUHATA Chieko 広島大学, 大学院・医歯薬学総合研究科, 助教 (10335664)
OHHARA Yukari 広島大学, 大学院・医歯薬学総合研究科, 助教 (80634469)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ミュータンスレンサ球菌 / う蝕 / プラークエコシステム / 酸性環境 / early childhood caries / 酸産生菌 |
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| Research Abstract |
A result of examining the properties obtained from mutans streptococci (MS) and plaque in children showed that the ratio of MS in plaque related to caries severity nature of MS. Apparent difference was found in expression level of caries-related genes in the acidic environment in particular between high caries group and low-caries group. On the other hand, the tendency of plaque formation inhibition was observed in the Aml study of dental caries in the rat experimental model. The basic results of the (patent) clinical application was obtained revealed the plaque produce inhibitory effect on MS of Pamis extract from grape containing a large amount of oleanolic acid.
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