2013 Fiscal Year Final Research Report
First malaria infection in infants on islands in Melanesia
| Project/Area Number |
22406008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Osaka City University |
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Principal Investigator |
KANEKO Akira 大阪市立大学, 医学(系)研究科(研究院), 教授 (60169563)
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| Co-Investigator(Renkei-kenkyūsha) |
CULLETON Richard 長崎大学, 熱帯医学研究所, 准教授 (10503782)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 島嶼マラリア / 三日熱マラリア / マラリア撲滅 / 防御免疫 / 年齢特異性 / ＰＣＲ診断 / ヴァヌアツ |
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| Research Abstract |
Aneityum, the southernmost island in Vanuatu, is located at the south-east edge of the malaria extension in the Pacific. To examine the feasibility of malaria elimination, an integrated program, combining mass drug administration (MDA) and vector control, was initiated on Aneityum in 1991. Microscopy showed Plasmodium falciparum immediately disappeared whereas P. vivax disappeared from 1996 onwards. Since 1991 community-based surveillance and vector control measures were continuously maintained. Eight years later, it was concluded that malaria can be eliminated from isolated islands if there is a high degree of community commitment. An epidemic of P. vivax on Aneityum in 2002 provided us with an opportunity to investigate resurgence. Adults born before elimination had considerably fewer episodes of parasitemia than children born after elimination, indicating that protective immunity against P. vivax infections persists for a long time after the initiation of malaria elimination.
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[Journal Article] Behavioral risk factors for obesity during health transition in Vanuatu, South Pacific2013
Author(s)
Dancause KN, Vilar M, Wilson M, Soloway LE, DeHuff C, Chan C, Tarivonda L, Regenvanu R, Kaneko A, Lum JK, Garruto RM
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Journal Title
Obesity (Silver Spring)
Volume: 21
Pages: E98-E104
DOI
Peer Reviewed
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[Journal Article] Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt2012
Author(s)
Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T
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Journal Title
Malaria Journal
Volume: 11
Pages: 92
DOI
Peer Reviewed
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[Journal Article] Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA52012
Author(s)
Tanabe K, Arisue N, Palacpac NMQ, Yagi M, Tougan T, Honma H, Ferreira MU, Farnert A, Bjorkman A, Kaneko A, Nakamura M, Hirayama K, Mita T, Horii T
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Journal Title
Vaccine
Volume: 30
Pages: 1583-1593
Peer Reviewed
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[Journal Article] Patterns of childhood and adolescent overweight and obesity during health transition in Vanuatu2012
Author(s)
Dancause KN, Vilar M, Chan C, DeHuff C, Wilson M, Soloway LE, Tarivonda L, Regenvanu R, Kaneko A, Garruto RM, Lum JK
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Journal Title
Public Health Nutrition
Volume: 15
Pages: 158-166
Peer Reviewed
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[Journal Article] Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax2011
Author(s)
Doi M, Tanabe K, Tachibana S-I, Hamai M, Tachibana M, Mita T, Yagi M, Zeyrek FY, Ferreira MU, Ohmae H, Kaneko A, Randrianarivelojosia M, Sattabongkot J, Cao Y-M, Horii T, Torii M, Tsuboi T.
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Journal Title
Vaccine
Volume: 29
Pages: 4308-4315
Peer Reviewed
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[Journal Article] The Origins of African Plasmodium vivax ; Insights from Mitochondrial Genome Sequencing2011
Author(s)
Culleton R, Coban C, Zeyrek F, Cravo P, Kaneko A, Randrianarivelojosia M, Andrianaranjaka V, Kano S, Farnert A, Arez AP, Carter R, Tanabe K
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Journal Title
Plos One
Volume: 6
Pages: e29137
Peer Reviewed
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[Journal Article] Behavioral changes associated with economic development in the South Pacific : Health transition in Vanuatu2011
Author(s)
Dancause KN, Dehuff C, Soloway LE, Vilar M, Chan C, Wilson M, Tarivonda L, Regenvanu R, Kaneko A, Garruto RM, Lum JK
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Journal Title
Am J Hum Biol
Volume: (Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Plasmodium falciparum : a stowaway in our ancestors' journey out of Africa2010
Author(s)
Tanabe K, Mita T, Jombart T, Palacpac N, Ranford-Cartwright L, Sawai H, Sakihama N, Horibe S, Ohmae H, Nakamura M, Ferreira MU, Escalante AA, Bjorkman A, Farnert A, Kaneko A, Horii T, Kishino H, Balloux F
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Journal Title
Current Biol
Volume: 20
Pages: 1283-1289
Peer Reviewed
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