2013 Fiscal Year Final Research Report
Immunogenetic analysis of early onset schistosomal fibrosis in the Philippines
| Project/Area Number |
22406009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
KIKUCHI Mihoko 長崎大学, 熱帯医学研究所, 講師 (40336186)
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| Co-Investigator(Kenkyū-buntansha) |
CHIGUSA Yuichi 獨協医科大学, 医学部, 教授 (20171936)
HIRAYAMA Kenji 長崎大学, 熱帯医学研究所, 教授 (60189868)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 日本住血吸虫 / フィリピン / 肝線維化症 / 免疫応答性 / 遺伝解析 / HLA-DRB1*1501 / mRNA |
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| Research Abstract |
Post-schistosomal hepatic fibrosis and cirrhosis are the major sequelae resulting from excessive immune response to deposited eggs in the portal area. In humans little is known about immunoregulatory mechanisms controlling the development of hepatosplenic disease. The objective of the study is to determine the prevalence of the early onset schistosomal fibrosis and the different host genetic factors and mechanism behind the immune responses in patients with early onset schistosomal liver fibrosis in the Sorsogon Province, Philippines. The subjects were subjected to Kato-katz stool examination, ultrasonographic examination, and detection of anti-SEA antibody, located in the schistosomiasis endemic barangays of the municipality of Irosin, in the province of Sorsogon. Results of imuunogenetical analysis showed measure immune-responses in early onset post schistosomal fibrosis was restricted HLA-DRB1*15:01 and progression was related on expression level of HLA-DRB1 gene.
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Research Products
(14 results)
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[Journal Article] Detection of active schistosome infection by cell-free circulating DNA of Schistosoma japonicum in highly endemic areas in Sorsogon Province, the Philippines2014
Author(s)
Kato-Hayashi N, Leonardo LR, Arevalo NL, Tagum MN, Apin J, Agsolid LM, Chua JC, Villacorte EA, Kirinoki M, Kikuchi M, Ohmae H, Haruki K, Chigusa Y
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Journal Title
Acta Trop
Volume: (pii : S0001-706X(14)00168-5)
DOI
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[Journal Article] Genetic Structure Inferred from Mitochondrial 12S Ribosomal RNA Sequence of Oncomelaniaquadrasi, the Intermediate Snail Host of Schistosoma japonicum in the Philippines2014
Author(s)
Weerachai Saijuntha, Blanca Jarilla, Alvin K. Leonardo, Louie S. Sunico, Lydia R. Leonardo, Ross H. Andrews, Paiboon Sithithaworn, Trevor N. Petney, Masashi Kirinoki, Naoko Kato-Hayashi, Mihoko Kikuchi, Yuichi Chigusa, and Takeshi Agatsuma
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Journal Title
American Jornal of Tropical Medicine and Hygene
Volume: (Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Use of cell-free circulating schistosome DNA in serum, urine, semen, and saliva to monitor a case of refractory imported schistosomiasis hematobia2013
Author(s)
Kato-Hayashi N, Yasuda M, Yuasa J, Isaka S, Haruki K, Ohmae H, Osada Y, Kanazawa T, Chigusa Y
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Journal Title
J Clin Microbiol
Volume: 51(10)
Pages: 3435-8
DOI
Peer Reviewed
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[Journal Article] Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum2012
Author(s)
Mbanefo EC, Chuanxin Y, Kikuchi M, Shuaibu MN, Boamah D, Kirinoki M, Hayashi N, Chigusa Y, Osada Y, Hamano S, Hirayama K
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Journal Title
BMC Genomics
Volume: 13
Pages: 260
DOI
Peer Reviewed
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[Book] 感染症事典2012
Author(s)
感染症事典編集委員会編共著菊池三穂子
Total Pages
617(住血吸虫pp527-532)
Publisher
オーム社
