2013 Fiscal Year Final Research Report
Population genetic analysis of dynamism of malaria drug resistance in Papua New Guinea
| Project/Area Number |
22406012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Juntendo University (2012-2013)
Tokyo Women's Medical University (2010-2011) |
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Principal Investigator |
MITA Toshihiro 順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Kazuyuki 大阪大学微生物学研究所, 招聘教授 (40047410)
TSUKAHARA Takahiro 東京女子医科大学, 医学部, 講師 (90328378)
HAYAKAWA Toshiyuki 九州大学, 基幹教育院, 准教授 (80418681)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 薬剤耐性 / 熱帯熱マラリア原虫 / クロロキン / ピリメサミン / ファンシダール / アルテミシニン / 集団遺伝 |
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| Research Abstract |
This study aimed to elucidate the dynamism of drug-resistant Plasmodium falciparum in Papua New Guinea where pyrimethamine and sulfadoxine were added to the first-treatment policy of malaria in 2000. We found significant selection of resistant-parasites to both antimalarial drugs. Emergence of resistance to pyrimethamine preceded sulfadoxine. Until 2011, all parasites harbored the resistant-related multi-locus mutations for chloroquine and pyrimethamine. Nearly 80% of parasites harbored resistant-related mutations for sulfadoxine, which migrated from Southeast Asia. Parasites showing resistance to artemisinin was not identified in the study period. This may be partly explained the fact that artemisinin combination therapy has been implemented in our study area around 2012 despite it was officially introduced in 2010.
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[Journal Article] Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite2014
Author(s)
Mita, T., Ohashi, J., Venkatesan, M., Marma, A. S., Nakamura, M., Plowe, C. V., & Tanabe, K
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Journal Title
J Infect Dis
Volume: 209
Pages: 130-139
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[Journal Article] A large scale survey for novel genotypes of the Plasmodium falciparum chloroquine-resistant p fcrt gene2012
Author(s)
Takahashi, N., Tanabe, K., Tsukahara, T., Dzodzomenyo, M.,Dysoley, L., Khamlome, B., Sattabongkot, J., Nakamura, M., Sakurai, M., Kobayashi, J., Endo, H., Hombhanje, F., Tsuboi, T., Mita, T
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Journal Title
Malaria J
Volume: 11
Pages: 92
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[Journal Article] Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations2011
Author(s)
Mita, T, Venkatesan, M, Ohashi, J, Culleton, R, Takahashi, N, Tsukahara, T, Ndounga, M, Dysoley, L, Endo, H, Hombhanje, F, Ferreira, M, Plowe, CV, Tanabe, K
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Journal Title
J Infect Dis
Volume: 204
Pages: 1980-1988
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[Journal Article] Spontaneous mutations in the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among wide geographical parasite populations unexposed to artemisinin-based combination therapies2011
Author(s)
Tanabe, K, Zakeri, S, Palacpac M, Afsharpad, M, Randrianarivelojosia M, Kaneko, A, Marma, AS, Horii, T, Mita, T
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Journal Title
Antimicrob Agents Chemother
Volume: 55
Pages: 94-100
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[Journal Article] Generation of Rodent Malaria Parasites with a High Mutation Rate by destructing Proofreading activity of DNA Polymerase
Author(s)
Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac N, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yssunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K
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Journal Title
DNA Res
Volume: (In press)
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