2012 Fiscal Year Final Research Report
Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers
| Project/Area Number |
22406016
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
MA Nei 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
MIDORIKAWA Kaoru 三重大学, 大学院・医学系研究科, リサーチアソシエイト (20393366)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 中国南部 / 上咽頭癌 / Epstein-Barrウィルス / 環境要因 / 酸化ニトロ化ストレス / DNA損傷 / DNAメチル化異常 |
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| Research Abstract |
Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is endemic in southern China. Questionnaire investigation suggested significant association between NPC and environmental factors such as smoking and foods. Strongimmunnoreactivities of 8-oxodG and 8-nitroguanine were observed in the cancer cells of NPC patients. The difference in the serum levels of 8-oxodG between the NPC patients and controls showed statistically significant, suggesting that 8-nitroguanine and 8-oxodG could be potential biomarkers for evaluating the risk of NPC. We revealed the epigenetic inactivation of several genes by promoter hypermethylation in NPC.
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[Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma2012
Author(s)
Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
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Journal Title
Free Radic. Biol. Med
Volume: 52(8)
Pages: 1465-72
Peer Reviewed
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[Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression. Biochem.2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
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Journal Title
Biophys. Res. Commun
Volume: 421
Pages: 280-285
Peer Reviewed
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[Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection2011
Author(s)
Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, Leithy TE, Hiraku Y, Amro el K, Oikawa S, Ohnishi S, Murata M、Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 414
Pages: 344-349
Peer Reviewed
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[Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury.2011
Author(s)
Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A.
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Journal Title
Neurobiol Dis
Volume: 43
Pages: 706-714
Peer Reviewed
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[Journal Article] TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.2010
Author(s)
Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G, Zhang Z
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Journal Title
BMC Cancer
Volume: 10
Pages: 617
Peer Reviewed
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[Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole2010
Author(s)
Furukawa A, 査読有Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S
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Journal Title
Mutat Res
Volume: 694(1-2)
Pages: 7-12
Peer Reviewed
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[Journal Article] High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double deficient mice.2010
Author(s)
Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K,Murata M, Murata T, Yano Y, Morser J, Gabazza EC, Takei Y.
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Journal Title
J Thromb Haemost.
Volume: 8(11)
Pages: 2514-22
Peer Reviewed
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[Journal Article] Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.2010
Author(s)
Mizutani H,Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S.
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Journal Title
Cancer Sci.
Volume: 101(10)
Pages: 2214-9
Peer Reviewed
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[Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress2012
Author(s)
Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi, Mariko Murata
Organizer
The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
Place of Presentation
Edinburgh, UK
Year and Date
20120722-26
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[Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis.2012
Author(s)
Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi and Mariko Murata.
Organizer
Mahidol International Conference on Infection and Cancer.
Place of Presentation
Bangkok, Thailand
Year and Date
20120206-08
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