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2012 Fiscal Year Final Research Report

Infection dynamics and molecular mechanisms of prevalence of new variant and emerging Rotaviruses prevailing in Asia

Research Project

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Project/Area Number 22406017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Hygiene
Research InstitutionSapporo Medical University

Principal Investigator

KOBAYASHI Nobumichi  札幌医科大学, 医学部, 教授 (80186759)

Co-Investigator(Kenkyū-buntansha) ISHINO Masaho  札幌医科大学, 医学部, 准教授 (30232325)
SUMI Ayako  札幌医科大学, 医学部, 准教授 (10363699)
URUSHIBARA Noriko  札幌医科大学, 医学部, 講師 (80396308)
GHOSH Souvik  札幌医科大学, 医学部, 助教 (30597175)
Project Period (FY) 2010 – 2012
Keywordsロタウイルス / 遺伝子型 / 新変異型 / 新興型 / 分子疫学 / アジア / 系統樹 / 遺伝子再集合(リアソートメント) / 遺伝子再集合体
Research Abstract

To elucidate genetic characteristics of new variants and emerging types of rotavirus that spread to mainly in Asian countries, whole genomic sequence analysis and phylogenetic analysis were conducted. In China and Bangladesh, the predominant genotypes were G1P[8]/G3P[8], G2P[4], respectively, among which reassortant viruses containing gene segments derived from animal rotavirus were detected. Rotaviruses with P[8]b, a new variant of P[8]-VP4 genotype, were detected in China, Bangladesh, and Myanmar, and mostly associated with globally emerging type G9. Whole genomic analysis of various rotaviruses strains with emerging genotypes from Asia and other regions (genotypes G1P[6], G2P[6], G3P[2]、G3P[6], G3P[9], G4P[10], G6P[9], G8P[1], G9P[19]) revealed that these strains could be classified into 1)reassortant between different human rotavirus genogroups, 2)reassortant between human and animal rotaviruses, and 3) animal rotaviruses that directly transmitted to humans. These findings indicated that reassortment and interspecies transmission may be the main causing mechanisms of new variants and emergingtypes of human rotaviruses.

  • Research Products

    (23 results)

All 2013 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (6 results)

  • [Journal Article] Effect of temperature, relative humidity, and rainfall on rotavirus infections in Kolkata,India.2013

    • Author(s)
      Sumi A, Rajendran K, Ramamurthy T, Krishnan T, Nair GB, Harigane K, Kobayashi N.
    • Journal Title

      Epidemiol Infect

    • Peer Reviewed
  • [Journal Article] Complex evolutionary patterns of two rare human G3P[9] rotavirus strains possessing a feline/canine-like H6 genotype on an AU-1-like genotype constellation.2013

    • Author(s)
      Wang Y-H, Pang B-B, Zhou X, Ghosh S, Tang W-F, Peng J-S, Hu Q, Zhou D-J, Kobayashi N.
    • Journal Title

      Infect Genet Evol

    • Peer Reviewed
  • [Journal Article] hole genomic analyses of asymptomatic human G1P[6], G2P[6] and G3P[6] rotavirus strains reveal intergenogroup reassortment events and genome segments of artiodactyl origin.2013

    • Author(s)
      Ghosh S, Urushibara N, Chawla-Sarkar M, Krishnan T, Kobayashi N.
    • Journal Title

      Infect Genet Evol

    • Peer Reviewed
  • [Journal Article] The origin of two rare human P[10] rotavirus strains.2013

    • Author(s)
      Ghosh S, Urushibara N, Kawaguchiya M, Shintani T, Kobayashi N
    • Journal Title

      Infect Genet Evol

      Volume: 13 Pages: 292-300

    • Peer Reviewed
  • [Journal Article] Whole genomic analysis of human G1P[8] rotavirus strains from different age groups in China.2012

    • Author(s)
      Shintani T, Ghosh S, Wang Y-H, Zhou X, Zhou D-J, Kobayashi N.
    • Journal Title

      Viruses

      Volume: 4 Pages: 1289-1304

    • Peer Reviewed
  • [Journal Article] Whole genomic analysis of a human G1P[9] rotavirus strain reveals intergenogroup reassortment events.2012

    • Author(s)
      Ghosh S, Shintani T, Urushibara N, Taniguchi K, Kobayashi N.
    • Journal Title

      J Gen Virol

      Volume: 93 Pages: 1700-1705

    • Peer Reviewed
  • [Journal Article] Prevalence of human rotavirus genotypes in Wuhan, China during 2008-2011 : changing trend of predominant genotype and emergence of strains with P[8]b subtype of VP4 gene.2011

    • Author(s)
      Wang Y-H, Zhou X, Ghosh S, Zhou D-J, Pang B-B, Peng J-S, Hu Q, Kobayashi N.
    • Journal Title

      Arch Virol

      Volume: 156 Pages: 2221-2231

    • Peer Reviewed
  • [Journal Article] Whole genomic analysis of rotavirus strains: current status and future prospects.2011

    • Author(s)
      Ghosh S, Kobayashi N.
    • Journal Title

      Future Microbiol

      Volume: 6 Pages: 1049-1065

    • Peer Reviewed
  • [Journal Article] Whole genomic analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains.2011

    • Author(s)
      Ghosh S, Adachi N, Gatheru Z, Nyangao J, Yamamoto D, Ishino M, Urushibara N, Kobayashi N.
    • Journal Title

      J Gen Virol

      Volume: 92 Pages: 2201-2208

    • Peer Reviewed
  • [Journal Article] Ghosh S, Paul SK, Yamamoto D, Nagashima S, Kobayashi N.2011

    • Author(s)
      Ghosh S, Paul SK, Yamamoto D, Nagashima S, Kobayashi N.
    • Journal Title

      Infect Genet Evol

      Volume: 11 Pages: 1481-1486

    • Peer Reviewed
  • [Journal Article] Detection and full genomic analysis of G6P[9] human rotavirus in Japan.2011

    • Author(s)
      Yamamoto D, Kawaguchiya M, Ghosh S, Ichikawa M, Numazaki K, Kobayashi N.
    • Journal Title

      Virus Genes

      Volume: 43 Pages: 215-223

    • Peer Reviewed
  • [Journal Article] Full genomic analyses of two human G2P[4] rotavirus strains isolated in 2005 : Identification of caprine-like VP3 gene.2011

    • Author(s)
      Ghosh S, Paul SK, Hossain MA, Alam MM, Ahmed MU, Kobayashi N.
    • Journal Title

      J Gen Virol.

      Volume: 92 Pages: 1222-1227

    • Peer Reviewed
  • [Journal Article] Emergence of G9 as a predominant genotype of human rotaviruses in Cuba.2011

    • Author(s)
      Ribas M, Nagashima S, Calzado A, Acosta G, Tejero Y, Cordero Y, PiedraD, Kobayashi N.
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 738-744

    • Peer Reviewed
  • [Journal Article] Yamamoto D, Ghosh S, Kuzuya M, Wang Y-H, Zhou X, Chawla-Sarkar M, Paul SK, Ishino M, Kobayashi N.2011

    • Author(s)
      Yamamoto D, Ghosh S, Kuzuya M, Wang Y-H, Zhou X, Chawla-Sarkar M, Paul SK, Ishino M, Kobayashi N.
    • Journal Title

      J Gen Virol

      Volume: 92 Pages: 361-369

    • Peer Reviewed
  • [Journal Article] Full Genomic analysis of a simian SA11-like G3P[2] Rotavirus strain isolated from an asymptomatic infant : identification of novel VP1, VP6, and NSP4 genotype.2011

    • Author(s)
      Ghosh S, Gatheru Z, Nyangao J, Adachi N, Urushibara N, Kobayashi N.
    • Journal Title

      Infect Genet Evol

      Volume: 11 Pages: 57-63

    • Peer Reviewed
  • [Journal Article] Full genomic analysis of a G8P[1] Rotavirus strain isolated from an asymptomatic infant in Kenya provides evidence for an artiodactyl-to-human interspecies transmission event.2011

    • Author(s)
      Ghosh S, Gatheru Z, Nyangao J, Adachi N, Urushibara N, Kobayashi N
    • Journal Title

      J Med Virol

      Volume: 83 Pages: 367-376

    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of human rotavirus in Myanmar : detection of Indian-Bangladeshi G1/G2 lineages, Chinese G3 lineage and OP354-like P[8] lineage (P[8]b subtype).2010

    • Author(s)
      Aung MS, Aung TS, Oo KY, Win N, Ghosh S, Yamamoto D, Kobayashi N.
    • Journal Title

      Southeast Asian J Trop Med Public Health

      Volume: 41 Pages: 1393-1404

    • Peer Reviewed
  • [Presentation] Interspecies transmission of rotaviruses evidenced by whole genomic sequence analysis2013

    • Author(s)
      Kobayashi N, Ghosh S.
    • Organizer
      The 17th FAVA (Federation of Asian Veterinary Association) congress
    • Place of Presentation
      Taipei
    • Year and Date
      20130000
  • [Presentation] Molecular epidemiological analysis of G3P[9] rotaviruses from diarrheal patients in China2012

    • Author(s)
      Kobayashi N, Wang YH, Zhou X, Pang BB, Liu MQ, Peng JS, Hu Q, Zhou DJ, Ghosh S.
    • Organizer
      he 13thAsia-Pacific congress of Clinical Microbiology and Infection
    • Place of Presentation
      Beijing
    • Year and Date
      20120000
  • [Presentation] Full genomic analysis of rare G6P[9] human rotavirus detected in Japan2011

    • Author(s)
      Yamamoto D, Kawaguchiya M, Ghosh S, Ichikawa M, Numazaki K, Kobayashi N.
    • Organizer
      15thInternational Congress of Virology
    • Place of Presentation
      Sapporo
    • Year and Date
      20110000
  • [Presentation] Full-genomic analysis of human rotavirus strains which have VP4 genes belonging to a rare P[8] subtype (P[8]B)2011

    • Author(s)
      Kobayashi N, Ghosh S, Paul SK, Nagashima S.
    • Organizer
      15thInternational Congress of Virology
    • Place of Presentation
      Sapporo
    • Year and Date
      20110000
  • [Presentation] Full genomic analysis of human G2P[4] rotavirus strains from Africa2011

    • Author(s)
      Ghosh S, Adachi N, Gatheru Z, Nyangao J, Ishino M, Urushibara N, Kobayashi N.
    • Organizer
      15thInternational Congress of Virology
    • Place of Presentation
      Sapporo.
    • Year and Date
      20110000
  • [Presentation] Full genomic analysis of an artiodactyl-like group A rotavirus G8P[1] strain detected from an asymptomatic infant in Kenya2010

    • Author(s)
      Ghosh S, Kobayashi N.
    • Organizer
      12th Western Pacific Congress on Chemotherapy and Infectious Diseases
    • Place of Presentation
      Singapore
    • Year and Date
      20100000

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Published: 2014-08-29  

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