2012 Fiscal Year Final Research Report
Assessment of Prevalence and Trends of Metabolic Syndrome among Bangladeshi Rural Women : From basic epidemiology to genetic screening
| Project/Area Number |
22406025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
HIROE Michiaki 独立行政法人国立国際医療研究センター, その他部局等, 非常勤医 (80101872)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メタボリック症候群 / 横断研究 / バングラデシュ国 / 農村部女性 / 生物マーカー |
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| Research Abstract |
Metabolic Syndrome (MS) has been replaced by 'global cardiometabolic risk, which is a complex disorder and an emerging clinical challenge. MS, defined as a constellation of cardiovascular disease (CVD) risk factors, is one of the growing public health burdens in the Asia-Pacific region, even though people in this region are no more overweight than Europeans and Americans. Comparative studies indicate that metabolic responses to obesity may be greater in South and East Asians than their western counterparts at given Body Mass Indexes (BMIs). But MS screening has only been done in a few countries of South East Asia, excluding Bangladesh. The present study was designed to conduct a comprehensive screening of metabolic syndrome in Bangladeshi rural women, including prevalence estimation and biomarker assessment. The clinical relevance of MS is that it identifies people who are at increased long-term risk of cardiovascular disease and type 2 Diabetes (T2DM), thus providing an opportunity for preventive lifestyle interventions.
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[Journal Article] statin agent, pitavastatin, normalizes aberrant signaling of VEGF and function of the heart in the STZ-induced diabetic rat model.2013
Author(s)
Jesmin S, Yamaguchi N, Iwashima Y, Shimojo N, Akter S, Moroi M, Okazaki O, Kawano Y, Hiroe M, Mizutani T
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Journal Title
European Journal of Pharmacology
Volume: (in press)
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[Journal Article] Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women.2013
Author(s)
Jesmin S, Akter S, Rahman MM, Islam MM, Islam AM, Sultana SN, Mowa CN, Yamaguchi N, Okazaki O, Satoru K, Kimura S, Hiroe M, Mizutani T, Moroi M
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Journal Title
Thrombosis and Haemostasis
Volume: 109(4)
Pages: 696-705
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[Journal Article] Metabolic syndrome among pre and post menopausal rural women in Bangladesh: result from a population based-study.2013
Author(s)
Jesmin S, Islam AMS, Akter S, Islam MM, Sultana SN, Yamaguchi N, Okazaki O, Moroi M, Hiroe M, Kimura S, Watanabe T, Saturo K, Mizutani T
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Journal Title
BMC Research Notes
Volume: 6
Pages: 157
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