Epidemiological study for association between Helicobacter infection and gastrointestinal diseases

2012 Fiscal Year Final Research Report

• Project/Area Number: 22406026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: AZUMA Takeshi 神戸大学, 医学研究科, 教授 (60221040)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Masaru 神戸大学, 医学研究科, 准教授 (00419475) ; KUTUMI Hiromu 神戸大学, 医学研究科, 医学研究科 (70420461)
• Project Period (FY): 2010 – 2012
• Keywords: Helicobacter感染 / 消化器疾患 / 疫学調査

Research Abstract

In this study, we investigated the relationship between Helicobacterinfection (H. pylori and H. suis) and gastrointestinal diseases in Asian and African countries. H. pyloriis a group I carcinogen in human. CagA is a most important virulent factor of H. pyloriassociate with gastric cancer. The prevalence of East Asian CagA was significantly higher in patients with gastric cancer than in patients with chronic gastritis. The much greater magnitude of risk observed with East Asian CagA-positive H. pyloriinfection. Therefore, patients harboring East Asian CagA-positive H. pylori are at a higher risk for developing gastric cancer than those infected with Western CagA-positive strains. H. suis, which belongs to the Helicobacterfamily just like H. pylori, was found in the stomachs of various animals including cats, dogs and pigs, and furthermore humans. H. suis infection caused gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Th1 host response was predominant in H. pyloriinfection. In contrast, both Th1 and Th2 host response were up-regulated in H. suisinfection.

Research Products

• [Journal Article] Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species (2012)
  • Author(s): Yahara K, Kawai M, Furuta Y, Takahashi N, Handa N, Tsuru T, Oshima K, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
  • Journal Title: Genome Biol Evol Volume: 4(5) Pages: 628-40
  • Peer Reviewed
• [Journal Article] IFN-γ plays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection. (2011)
  • Author(s): Mimura T, Yoshida M, Nishiumi S, Tanaka H, Nobutani K, Takenaka M, Suleiman YB, Yamamoto K, Ota H, Takahashi S, Matsui H, Nakamura M, Miki I, Azuma T.
  • Journal Title: FEMS Immunol Med Microbiol. Volume: 63(1) Pages: 25-34
  • Peer Reviewed
• [Journal Article] Dual roles of CagA protein in Helicobacterpylori--induced chronic gastritis in mice. (2011)
  • Author(s): Kido M, Watanabe N, Aoki N, Iwamoto S, Nishiura H, Maruoka R, Ikeda A, Azuma T, Chiba T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 412(2) Pages: 266-72
  • Peer Reviewed
• [Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells. (2011)
  • Author(s): Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T.
  • Journal Title: Microbes Infect Volume: 13(7) Pages: 697-708
  • Peer Reviewed
• [Journal Article] Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pyloriEast Asian genomes. (2011)
  • Author(s): Kawai M, Furuta Y, Yahara K, Tsuru T, Oshima K, Handa N, Takahashi N, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
  • Journal Title: BMC Microbiol Volume: 11 Pages: 104
  • Peer Reviewed
• [Journal Article] Birth and death of genes linked to chromosomal inversion. (2011)
  • Author(s): Furuta Y, Kawai M, Yahara K, Takahashi N, Handa N, Tsuru T, Oshima K, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108(4) Pages: 1501-6
  • Peer Reviewed
• [Journal Article] Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway. (2010)
  • Author(s): Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensuleiman Y, Ota H, Takahashi S, Matsui H, Nakamura M, Azuma T.
  • Journal Title: FEMS Immunol Med Microbiol Volume: 60(2) Pages: 156-64
  • Peer Reviewed
• [Journal Article] Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis. (2010)
  • Author(s): Mizuno S, Miki I, Ishida T, Yoshida M, Onoyama M, Azuma T, Habu Y, Inokuchi H, Ozasa K, Miki K, Watanabe Y.
  • Journal Title: Dig Dis Sci Volume: 55(11) Pages: 3132-7
  • Peer Reviewed
• [Journal Article] Diversity of the cagA gene of Helicobacter pylori strains from patients with gastroduodenal diseases in the Philippines. (2010)
  • Author(s): Cortes MC, Yamakawa A, Casingal CR, Fajardo LS, Juan ML, De Guzman BB, Bondoc EM; St. Luke's Helicobacter pylori Study Group, Mahachai V, Yamazaki Y, Yoshida M, Kutsumi H, Natividad FF, Azuma T.
  • Journal Title: FEMS Immunol Med Microbiol. Volume: 60(1) Pages: 90-7
  • Peer Reviewed
• [Journal Article] The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice. (2010)
  • Author(s): Tanaka H, Yoshida M, Nishiumi S, Ohnishi N, Kobayashi K, Yamamoto K, Fujita T, Hatakeyama M, Azuma T.
  • Journal Title: Arch Biochem Biophys. Volume: 498(1) Pages: 35-42
  • Peer Reviewed
• [Presentation] Bacterial virulence factors-Helicobacter pylori strain diversities in Asia (2012)
  • Author(s): Takeshi Azuma
  • Organizer: APDW
  • Place of Presentation: Bangkok Thailand
  • Year and Date: 20121207-08
• [Presentation] Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates the bacterial infection in mice. (2010)
  • Author(s): ヤハヤ ベンスレイマン
  • Organizer: 第16回日本ヘリコバクター学会
  • Place of Presentation: 京都
  • Year and Date: 20100624-25