2012 Fiscal Year Final Research Report
A fundamental research on a new AIDS treatment based on an error rate control of HIV-1 reverse transcriptase
| Project/Area Number |
22500273
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
HARADA Koji 豊橋技術科学大学, 大学院・工学研究科, 助教 (40390504)
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| Project Period (FY) |
2010 – 2012
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| Keywords | HIV / HIV 逆転写酵素 / 変異原 / ポピュレーションダイナミクス / 擬種 |
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| Research Abstract |
The present project aims to establish theoretical bases on an alternative AIDS treatment for ART, which simultaneously administers multiple anti-HIV drugs to an AIDS patient. It is well known that HIV-1 is frequently-mutated. The alternative AIDS treatment is by inducing excess mutations to HIV-1 RNA(+) genome, to drive HIV-1 quasi-species population to self-destruction. Namely it uses the HIV-1error-prone character as an underhanded way. This project proposes a novel HIV-1 mathematical model considered viral kinetic processes such as mutation, replication, infection and mutagenic activities to control HIV-1 mutation rate. Numerical simulations of the model show that enhancement of a HIV-1 mutation rate causes an “error catastrophe”to HIV-1 quasi-species population. Furthermore, analyses of local asymptotic stability of the self-destruction state reveal that the alternative AIDS treatment haseffectiveness under certain specific viral conditions.
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