2012 Fiscal Year Final Research Report
Prediction of carbohydrate chain-protein interaction by using carbohydrate chain structure information and its experimental verification
| Project/Area Number |
22500276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
ITO Masahiro 立命館大学, 生命科学部, 教授 (50388112)
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| Co-Investigator(Kenkyū-buntansha) |
ITONORI Saki 滋賀大学, 教育学部, 教授 (90324558)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖鎖 / 相互作用 / MD 計算 / 構造 / SVM |
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| Research Abstract |
The interaction of carbohydrate chains was analyzed to the 7 types of carbohydrate chains by using molecular dynamics simulation. We suggested three factors of changing the conformation. Moreover, we predicted inhibitory activity of two lipid mediators using support vector machine. The predicted chemical structures were analyzed a partial structures for activity in detail.
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