2012 Fiscal Year Final Research Report
Studies on motor axon guidance in a spontaneous mutant mouse
Project/Area Number |
22500284
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MASU Masayuki 筑波大学, 医学医療系, 教授 (20243032)
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Co-Investigator(Renkei-kenkyūsha) |
ARINAMI Tadao 筑波大学, 医学医療系, 教授 (10212648)
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Project Period (FY) |
2010 – 2012
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Keywords | 脳・神経 / 遺伝子 / 発生・分化 / 神経科学 |
Research Abstract |
The molecular mechanisms that regulate guidance of spinal motor axons to their target muscles are not known. In this study, we tried to elucidate it using a spontaneous mutant mouse that shows abnormalities in a particular motor trajectory. We examined the sequences of the genes in the critical region but failed to find any mutation responsible for the mutant phenotype. However, we found that the expression levels of several genes present in the critical region are changed in the mutant mice, suggesting the abnormalities in gene regulation.
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[Journal Article] ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cell Lines2013
Author(s)
Wang, R., Iwakura, Y., Araki, K., Keino-Masu, K., Masu, M., Wang, X., Takei, N., Higashiyama, S. and Nawa, H.
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Journal Title
Potential Contribution of Their Low-Affinity Interaction. Scientific reports
Volume: 3
Pages: 1402
Peer Reviewed
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[Journal Article] Organ-Specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice2012
Author(s)
Nagamine, S., Tamba, M., Ishimine, H., Araki, K., Shiomi, K., Okada, T., Ohto, T., Kunita, S., Takahashi, S., Wismans, R.G.P., van Kuppevelt, T.H., Masu, M., and Keino-Masu, K
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Journal Title
Journal of Biological Chemistry
Volume: 287
Pages: 9579-9590
Peer Reviewed
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[Journal Article] Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd12011
Author(s)
Terawaki, S., Yano, K., Katsutani, T., Shiomi, K., Keino-Masu, K., Masu, M., Shomura, Y., Komori, H., Shibata, N., and Higuchi, Y
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Journal Title
Acta Crystallographica
Volume: F67
Pages: 758-761
Peer Reviewed
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[Journal Article] Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development.2011
Author(s)
Koike, S., Yutoh, Y., Keino-Masu, K., Noji, S., Masu, M., and Ohuchi, H
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Journal Title
Developmental Dynamics
Volume: 240
Pages: 413-421
Peer Reviewed
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[Journal Article] Association of the HSPG2 Gene with Neuroleptic-Induced Tardive Dyskinesia2010
Author(s)
Syu, A., Ishiguro, H., Inada, T., Horiuchi, Y., Tanaka, S., Ishikawa, M., Arai, M., Itokawa, M., Niizato, K., Iritani, S., Ozaki, N., Takahashi, M., Kakita, A., Takahashi, H., Nawa, H., Keino-Masu, K., Arikawa-Hirasawa, E., and Arinami, T.
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Journal Title
Neuropsychopharmacology
Volume: 35
Pages: 1155-1164
Peer Reviewed
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[Presentation] Role of podocyte extracellular sulfatase in regulation of glomerular permeability.2012
Author(s)
Takashima, Y., Yamashita, H., Sakamoto, K., Hara, S., Kobayashi, N., Ueno, T., Keino-Masu, K., Masu, M., and Nagata, M.
Organizer
Kideney week 2012
Place of Presentation
San Diego Convention Center , San Diego, 米国
Year and Date
20121030-1104
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[Presentation] Heparan Sulfate Modification by Endosulfatases is Required for Cortical Axon Guidance2012
Author(s)
Masu, M., Okada, T., Nagamine, S., Ohto, T., Kametani, F., Hasegawa, M., Kunita, S., Takahashi, S., and Keino-Masu, K
Organizer
1^<st>international symposium/ 59^<th>NIBB conferences "Neocortical organization"
Place of Presentation
岡崎カンファレンスセンター、岡崎
Year and Date
20120310-13
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[Presentation] Autotaxin is required for anterior neural ridge formation, midbrain-hindbrain boundary patterning, and cranial neural tube closure.2010
Author(s)
Tagiuchi, E., Koike, S., Yutoh, Y. ,Keino-Masu, K., Noji, S., Masu, M., Ohuchi, H
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
Place of Presentation
神戸国際会議場、神戸
Year and Date
20101207-10
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[Presentation] Heparan sulfate 6-Oendosulfatases are required for neural network formation.2010
Author(s)
Okada, T., Keino-Masu, K., Nagamine, S., Kunita, S., Takahashi, S., and Masu, M
Organizer
The 40th Annual meeting of the Society for Neuroscience
Place of Presentation
San Diego, convenction center, San Diego,米国
Year and Date
20101113-17
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