2012 Fiscal Year Final Research Report
Studies on the reguratory mechanisms for maintainenance and differentiation of neural stem cells in the developmental brain
| Project/Area Number |
22500289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 発生 / 発達 / 再生神経科学 |
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| Research Abstract |
Genome-wide transcriptome profiles of single mouse cortical progenitors identified a set of temporally-regulated genes in embryonic neural stem cells (NSCs). Early NSCs showed cell-to-cell variations of Notch signaling-related gene expression, while later NSDs were more homogenous in Notch signaling status, suggesting a shift of NSC-maintaining strategy. I also found that neither initial oscillatory Notch activation nor cell cycle progression is necessary for NSCs’ internal “clock” mechanisms.
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