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2012 Fiscal Year Final Research Report

Functional analysis of nectin and afadin system in synaptogenesis

Research Project

  • PDF
Project/Area Number 22500293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKobe University

Principal Investigator

TOGASHI Hideru  神戸大学, 大学院・医学研究科, 助教 (90415240)

Project Period (FY) 2010 – 2012
Keywords樹状突起 / 細胞間接着 / ZO-1 / ネクチン / カドヘリン
Research Abstract

Neuronal dendrites and their branches dynamically protrude many fine filopodia in the early stages of neuronal development thatgradually establish complex structures, but the role of these dendritic filopodia in dendritic arborization is unknown. The MAGUK family member, ZO-1, was concentrated at the filopodia-filopodia contact sites. Overexpression or knockdown of ZO-1 affected thedynamics of dendritic filopodial protrusions and their interactions, causing abnormaldendrite morphologies. These results indicate that ZO-1 regulates dendritic filopodialdynamics, and therefore dendrite morphogenesis, in cultured neurons.

  • Research Products

    (5 results)

All 2013 2011 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] 中枢神経系の神経突起間認識とシナプス形成における細胞接着分子の働き2013

    • Author(s)
      富樫英
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡市
    • Year and Date
      20130321-23
  • [Presentation] Localization of nectin-1 at dendro-dendritic contacts between mitral/tufted cells in the external plexiform layer of mouse olfactory bulb2011

    • Author(s)
      井上貴仁、力武良行、富樫英、三好淳、溝口明、高井義美
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      20111213-16
  • [Presentation] マウス海馬神経細胞のシナプス形成におけるアファディンの役割2011

    • Author(s)
      豊嶋大作、富樫英、出来祐子、三好淳、萬代研二、高井義美
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      20110921-24
  • [Presentation] 細胞接着分子によるシナプス形成の分子機構2011

    • Author(s)
      富樫英
    • Organizer
      第27回 Wako ワークショップ「記憶の形成と障害~基礎から臨床まで」
    • Place of Presentation
      東京都品川区
    • Year and Date
      2011-11-22
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/mcb/

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Published: 2014-08-29  

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