2012 Fiscal Year Final Research Report
Comprehensive analysis of neural differentiation programs in the neural circuit formation
| Project/Area Number |
22500295
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
ONO Katsuhiko 京都府立医科大学, 医学研究科, 教授 (30152523)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOMURA Tadashi 京都府立医科大学, 医学研究科, 准教授 (10323007)
GOTOH Hitoshi 京都府立医科大学, 医学研究科, 助教 (20462202)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAKEBATASHI Hirohide 新潟大学, 医歯学総合研究科, 教授 (60353439)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 転写因子 / 間脳 / 転写因子 / 軸索ガイダンス分子 / Olig2 / Dlx2 / EphA3 |
|---|
| Research Abstract |
To understand mechanisms underlying neural circuit formation, we analyzed Olig2 function on the diencephalon formation including thalamocortical projection formation. Olig2 deficient mouse shows malformation (reduced size) of the prethalamus and expansion of the thalamic eminence. In addition, thalamocortical axons follow tortuous courses. The prethalamus has long been regarded as an intermediate target for the thalamocortical projection formation. Our results indicate that Olig2 regulates prethalamus formation, and also thalamocortical projection formation with an indirect manner. These results have been submitted to Development, an international journal for developmental biology, and now under revision.
|
