2012 Fiscal Year Final Research Report
Optogenetic analysis of neural functions in zebrafish
| Project/Area Number |
22500299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute of Genetics (2011-2012)
大学共同利用機関法人情報・システム研究機構(新領域融合研究センター、DBCLS) (2010) |
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Principal Investigator |
MUTO Akira 国立遺伝学研究所, 個体遺伝研究系, 助教 (00525991)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ゼブラフィッシュ / カルシウムイメージング / GCaMP / 視覚 / 脳 / 神経回路 / 光遺伝学 / オプトジェネティクス |
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| Research Abstract |
To understand how the brain works, it is desirable to visualize neuronal activity in the neuronal network and to evaluate the effect of blockade or stimulation of neuronal activity. Electrical activity of the neurons can be indirectly monitored by measuring the calcium influx via voltage-dependent calcium channels. We used zebrafish larvae as a model system to visualize neuronal activity in a specific subset of neurons. Furthermore, we developed optogenetic tools that can be applied in manipulation of neuronal activity
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[Journal Article] Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish2012
Author(s)
Hirata H, Wen H, Kawakami Y, Naganawa Y, Ogino K, Yamada K, Saint-Amant L, Low SE, Cui WW, Zhou W, Sprague SM, Asakawa K, Muto A, Kawakami K, Kuwada JY
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Journal Title
J Biol Chem
Volume: 287(2)
Pages: 1080-9
DOI
Peer Reviewed
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[Journal Article] zTrap: zebrafish gene trap and enhancer trap database2010
Author(s)
Kawakami K, Abe G, Asada T, Asakawa K, Fukuda R, Ito A, Lal P, Mouri N, Muto A, Suster ML, Takakubo H, Urasaki A, Wada H, Yoshida M
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Journal Title
BMC developmental biology 10 105 Oct 2010
Volume: 105
DOI
Peer Reviewed
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