2012 Fiscal Year Final Research Report
Comprehensive analysis of hippocampal neurogenesis from embryonic to postnatal stages
| Project/Area Number |
22500306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 成体期 / 胎生期 / ニューロン新生 / 海馬 / 神経幹細胞 |
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| Research Abstract |
In the hippocampus, neurons (granule cells) exceptionally continue to be generated into adulthood. There are adult type neural stem cells that express glial fibrillary acidic protein (GFAP), unlike usual embryonic ones. In this study, we explored the developmental process of neural stem cells producing granule cells from embryonic to early postnatal stages using transgenic mice to visualize GFAP expressing cells. The present results demonstrate that these embryonic neural stem cells express GFAP from the beginning of granule cell production.
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