2012 Fiscal Year Final Research Report
in vivo analysis of NG2+ cells
| Project/Area Number |
22500316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
MORI Tetuji 関西医科大学, 医学部, 講師 (30285043)
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| Project Period (FY) |
2010 – 2012
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| Keywords | NG2 細胞 / 神経幹・前駆細胞 |
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| Research Abstract |
NG2 is one of chondroitin sulfate proteoglycans. NG2+ cells are abundant in the adult brain. The function of NG2+ cells is not clear, but it is suggested that NG2+ cells can be multi-potent in in vitro culture system. In this study, I analyzed the function of NG2+ cells in vivo. Because previous studies show that excessive neuronal excitation induce proliferation of NG2+ cells, I analyzed and compared responses of NG2+ cells and endogenous neural stem/precursors against neuronal excitation in the seizure model mice. Present study showed that these precursors exhibit differential responses in terms of cell cycle progression.
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