2012 Fiscal Year Final Research Report
Functional analysis for differentiation and survival mechanism of excitatory neurons during the formation of cerebral cortex.
| Project/Area Number |
22500318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
OKADO Haruo 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (60221842)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Chiak 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (00281626)
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| Project Period (FY) |
2010 – 2012
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| Keywords | RP58 / 大脳皮質 / 転写抑制 |
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| Research Abstract |
We found that RP58 enhanced the cell-cycle exit resulting in neurogenesis via transcriptional repression of Id1-4 genes. In addition, we found that RP58 controls neuronal migration via transcriptional repression of Ngn2 gene independent on the cell cycle exit. This shows that RP58 is multifunctional regulator that suppresses the different downstream genes.
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[Journal Article] Developmental expression of sorting nexin 3 in the mouse central nervous system2011
Author(s)
Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A
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Journal Title
Gene Expr Patterns
Volume: 11
Pages: 33-40
DOI
Peer Reviewed
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