2012 Fiscal Year Final Research Report
Identification of glioma progenital cells and their niche
| Project/Area Number |
22500323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
|---|
Principal Investigator |
KOMORI Takashi 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (90205526)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SASAKO Atsushi 埼玉医科大学, 医学部, 教授 (80225862)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 悪性神経膠腫 / 前駆細胞 / 病理形態 / 遺伝子解析 / 乏突起膠腫 |
|---|
| Research Abstract |
In the first step of the study, anti-CSPG4 antibodies, a maker for NG2 glia, failed to disclose constituent tumor cells in human malignant glioma tissues. We then characterized oligodendroglioma that express Olig2, a transcription factor acted on oligodendrocyte progenitors. Our study revealed that classic oligodendroglioma is a distinct monoclonal tumor that harbors isocitrate dehydrogenases-1 (IDH1) R132H mutation and chromosome 1p/19 co-deletion but lacks p53 and CIC expression.
|
