2012 Fiscal Year Final Research Report
Peripheral nerve degeneration and regeneration from the viewpoint of neuron-Schwann cell interplay
| Project/Area Number |
22500324
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
|---|
Principal Investigator |
SANGO Kazunori 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (50291943)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATABE Kazuhiko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (30240477)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 筋 / 末梢神経疾患 |
|---|
| Research Abstract |
By employing cultured adult rat neurons and Schwann cells, we investigated the mechanisms of peripheral nerve degeneration and regeneration. The research suggests that galectin-1 is localized to small diameter dorsal root ganglion (DRG) neurons and Schwann cells and plays a role in GDNF-induced axonal regeneration. Moreover, an immortalized Schwann cell line IFRS1 established from adult Fischer 344 rats retains the fundamental ability to myelinate axons in coculture with DRG neurons and NGF-primed PC12 cells, thereby being a valuable tool for the study of demyelination and remyelination.
|
