2012 Fiscal Year Final Research Report
α-synuclein-positive neurites as an early diagnostic indicator
| Project/Area Number |
22500325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
UCHIHARA Toshiki 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (10223570)
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| Co-Investigator(Renkei-kenkyūsha) |
ORIMO Satoshi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (10392359)
HASHIMOTO Makoto 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (50189502)
WADA Masaaki 大阪大学, 情報科学研究所, 教授 (80192821)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経変性疾患 / シヌクレイン / パーキンソン病 / 電子顕微鏡 |
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| Research Abstract |
We traced the Lewy pathology in human brain and demonstrated its initiation at distal axon and subsequent centripetal extension. Expected dysfunction at distal axons, detectable as a decreased myocardial uptake of MIBG, is a reasonable candidate for early and specific diagnosis of Lewy body disease. In contrast, tau deposition start as 4R deposits in dendrites, which may undertake transition to 3R tau with centripetal progression, as we demonstrated with double labeling for 3R/4R tau. We also established a new method to compare light and immunoelectron microscopic findings of the same lesion, which is potentially useful to bridge molecular changes to lesion formation.
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[Journal Article] Lrrk2 i2020t mutation is associated with tau pathology2012
Author(s)
Ujiie S, Hatano T, Kubo S, Imai S, Sato S, Uchihara T, Yagishita S, Hasegawa K, Kowa H, Sakai F, Hattori N
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Journal Title
Parkinsonism Relat Disord
Volume: 18
Pages: 819-823
Peer Reviewed
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[Journal Article] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of tdp-432012
Author(s)
Uchida A, Sasaguri H, Kimura N, Tajiri M, Ohkubo T, Ono F, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Yamamoto M, Yokota S, Kubodera T, Tomori M, Sakaki K, Enomoto M, Hirai Y, Kumagai J, Yasutomi Y, Mochizuki H, Kuwabara S, Uchihara T, Mizusawa H, Yokota T
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Journal Title
Brain
Volume: 135
Pages: 833-846
Peer Reviewed
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[Presentation] MIBG 心筋シンチグラフィによる前頭側頭葉変性症とレビー小体型認知症の鑑別2011
Author(s)
稲葉彰, 坂本昌巳, 橋本祐二, 吾妻玲欧, 織茂智之, 服部高明, 三村将, 福井俊哉, 伊藤憲嘉, 内原俊記, 若林孝一, 高橋均, 柿田明美
Organizer
第52回日本神経学会学術大会
Place of Presentation
名古屋国際会議場
Year and Date
2011-05-18
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