2012 Fiscal Year Final Research Report
Analysis of the vascular degeneration mechanism in familial vascular dementia CADASIL
| Project/Area Number |
22500327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
WATANABE Atsushi 独立行政法人国立長寿医療研究センター, 共同利用推進室, 室長 (90321843)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 認知症 / 脳神経疾患 / プロテオーム |
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| Research Abstract |
We previously reported that the aggregate-prone property of mutant Notch3 might contribute to a pathogenic mechanism underlying familial vascular dementia CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). In this study, we searched for low-molecular compounds that decrease the amount of mutant Notch3 aggregates using the mutant Notch3 inducible stable cell lines. Furthermore, we analyzed the morphological and molecular changes by mutant Notch3 using the knock-in mice.
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