2012 Fiscal Year Final Research Report
Analysis of novel intracellular signal transduction mechanism of metabotropic glutamate receptor.
| Project/Area Number |
22500332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
MORIYOSHI Koki 京都大学, 医学部附属病院, 医員 (50263091)
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| Project Period (FY) |
2010 – 2012
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| Keywords | mGluR / スリーハイブリッド / 細胞内情報伝達 |
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| Research Abstract |
Metabotropic glutamate receptors (mGluRs) play crucial roles in higher brain functions such as learning and memory formation. The purpose of this researchproject is to identify novel signal transduction mechanisms of mGluRs and to elucidate the whole picture of mGluR-mediated regulation of synaptic function. Analysis of characteristic long C-terminal intracellular domain of mGluR1a revealed novel protein regions that controls intracellular localization of receptor molecules. Furthermore, screening of cDNA library using newly-developed yeast three-hybrid system successfully identify novel mGluR-interacting molecules. These results may improve the molecular understanding of synaptic regulation of central nervous system, and newly-identified molecules may become the candidate of drug development for neuropsychiatric diseases.
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