2012 Fiscal Year Final Research Report
Regulation of nitric oxide / reactive oxygen species signal by neuronal nitric oxide synthase
| Project/Area Number |
22500337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
IHARA Hideshi 大阪府立大学, 大学院・理学系研究科, 准教授 (60254447)
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| Project Period (FY) |
2010 – 2012
|
| Keywords | 細胞内情報伝達 / 一酸化窒素-活性酸素 |
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| Research Abstract |
nNOS producs not only NO, but also ROS through uncoupling reaction. In this study, we investigated NO/ROS signaling, a novel concept for cellular signal transduction. In PC12 cells expressing nNOS splice variants, treatment with MPP+activated the NO/ROS signaling to form a second messenger, 8-nitro-cGMP. We found a novel signal pathway leading to cell death through 8-nitro-cGMP formation.
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Research Products
(34 results)
