2012 Fiscal Year Final Research Report

Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline

Research Project

Project/Area Number	22500346
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neurochemistry/Neuropharmacology
Research Institution	National Center of Neurology and Psychiatry
Principal Investigator	YAMADA Mitsuhiko 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 部長 (60240040)
Co-Investigator(Kenkyū-buntansha)	SAITOH Akiyoshi 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 室長 (00366832) YAMADA Misa 独立行政法人国立精神・神経医療研究センター, 精神保健研究所精神薬理研究部, 科研費研究員 (10384182)
Project Period (FY)	2010 – 2012
Keywords	行動薬理 / 神経可塑的変化 / 遺伝子発現
Research Abstract	In the present study, we examined the expression of several neuroplasticity-related genes by real-time RT-PCR in the ventral and dorsal dentate gyrus of mice after the sertraline treatment. The gene encoding the neuropeptide galanin was significantly induced in only ventral dentate gyrus, not in dorsal dentate gyrus. These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression.

(3 results)