2012 Fiscal Year Final Research Report
Modulatory effects ofperineuronalglial cells on neuronal activities of pyramidal cells
| Project/Area Number |
22500352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Research Collaborator |
KANEKO Kenya 山形大学, 医学部, 技術専門職員
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| Project Period (FY) |
2010 – 2012
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| Keywords | 海馬 / グリア / 錐体細胞 / 活動電位 / 発火周波数 / CA1 |
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| Research Abstract |
We identified perineuronal glial cells (PNG) of pyramidal cells in CA1 region of the rat hippocampus. The maximum firing frequency of the pyramidal cells accompanying the PNG was significantly smaller than that of the pyramidal cells without PNG. Direct depolarization of PNG increased the firing frequency of action potentials of pyramidal cells, especially in the initial phase of the depolarization. These results indicate that the PNG modulate the activity of pyramidal cells constitutively and activity-dependently.
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Research Products
(13 results)
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[Journal Article] NMDA receptor-mediated Ca^<2+> influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices2012
Author(s)
Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
Volume
137
Pages
499-511
DOI
Peer Reviewed
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[Journal Article] Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyl transferase gene transgenic mice2011
Author(s)
Ikarashi K, Fujiwara H, Yamazaki^* Y, Goto JI, Kaneko K, Kato H, Fujii S, Sasaki H, Fukumoto S, Furukawa K, Waki H, Furukawa K.
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Journal Title
corresponding^* author
Volume: 21
Pages: 1373-1381
DOI
Peer Reviewed
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