2012 Fiscal Year Final Research Report
Studying the neural network involving the innate behavior in the olfactory system
| Project/Area Number |
22500354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Harumi 東京大学, 大学院・理学系研究科, 特任助教 (20311342)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 嗅覚受容体 / 恐怖行動 / 神経回路 |
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| Research Abstract |
The aim of present study is to investigate the neural network of fear response behavior coursed by the stimulation of fox odor “2,4,5-trimethylth iazoline (TMT)”. In order to clarify the functional domain of freezing behavior in the brain, we first identified the ORs (olfactory receptors) specifically activated by TMT and making the knock-out and knock-in mouse for the deletion and activation of olfactory neurons using these ORs. We also established the assay system analyzing the neural activity and behavior using unanesthetized mouse.
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