2012 Fiscal Year Final Research Report
Analysis of molecular integration by basal membrane in synapse formation and maintenance.
| Project/Area Number |
22500356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ニューロン / シナプス / 神経回路 / 基底膜 |
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| Research Abstract |
A physiological roles of molecular integration in synapse was studied by analysis of MAGI1 which indirectly binds to basal membrane. Biochemical and histochemical analysis revealed that MAGI1 was expressed in neuronal cells and localized on post synapse in brain. MAGI1 knockout mice showed abnormal anxiety -like and attention behaviour. In conlusion, molecular integration was required for normal synapse function and behavior.
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Research Products
(4 results)
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[Journal Article] The distribution of transient receptor potential melastatin-8in the rat soft palate, epiglottis, and pharynx.2013
Author(s)
Sato T, Fujita M, Kano M, Hosokawa H, Kondo T, Suzuki T, Kasahara E, Shoji N, Sasano T, Ichikawa H.
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Journal Title
Cell Mol Neurobiol
Volume: 33
Pages: 161-5
DOI
Peer Reviewed
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