The role of ghrelin in thermo and blood pressure regulation bythe autonomic nervous system

2012 Fiscal Year Final Research Report

• Project/Area Number: 22500361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kurume University
• Principal Investigator: MIFUNE Hiroharu 久留米大学, 医学部, 准教授 (70174117)
• Co-Investigator(Kenkyū-buntansha): SATO Takahiro 久留米大学, 分子生命科学研究所, 准教授 (50368883)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
• Project Period (FY): 2010 – 2012
• Keywords: グレリン / 自律神経機能 / 血圧調節機構 / グレリン遺伝子欠損マウス / 日内リズム / テレメトリー自動計測システム

Research Abstract

Ghrelin, the only circulating orexigenic hormone, increases appetite and food intake by stimulating the hypothalamic arcuate nucleus through vagal afferent neurons. Although ghrelin has been reported to play a crucial role in the regulation of the autonomic nervous system, its precise mechanisms or physiological relevance is not completely elucidated yet. Here we explored the existence of an abnormal circadian rhythm of blood pressure (BP), heart rate (HR) and body temperature (BT) in ghrelin knockout (ghrl-/-) mice using telemetric automatic analysis system. It has been demonstrated that ghrelin, secreted from stomach, controls the tone balance of BP, HR, and BT through the regulation of central autonomic nervous system. Thus, ghrelin is a hormone to maintain the homeostasis of the autonomic nervous system as well as anaccelerating factor of food intake.

Research Products

• [Journal Article] Disrupted Regulation of Ghrelin Production Under Antihypertensive Treatment in Spontaneously Hypertensive Rats.
  • Author(s): Naokazu Hamada, Yoshihiro Nishi, Yuji Tajiri, Kentaro Setoyama, Ryozo Kamimura, Kenkichi Miyahara, Norihito Nuruki, Hiroshi Hosoda, Kenji Kangawa, Masayasu Kojima, Hiroharu Mifune
  • Journal Title: Circulation Journal
  • Peer Reviewed
• [Presentation] 分泌顆粒内でのアシル化グレリンの分布・動態:免疫電顕を用いた解析. (2013)
  • Author(s): 西芳寛,御船弘治,矢吹映,田尻祐司,平田留美子,田中永一郎,細田洋司,寒川賢治,児島将康
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 20130425-0427
• [Presentation] 摂食促進ホルモン・グレリンによる自律神経機能の体温調節メカニズム. (2012)
  • Author(s): 御船弘治,佐藤貴弘,寒川賢治,児島将康
  • Organizer: 第59回日本実験動物学会総会
  • Place of Presentation: 別府市
  • Year and Date: 20120524-0526
• [Presentation] グレリンの産生・分泌に対する降圧剤の影響:SHR,WKYラットを用いた検討. (2012)
  • Author(s): 西芳寛,濱田直和,田尻祐司,田中永一郎,細田洋司,寒川賢治,児島将康,宮原健吉,御船弘治
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 20120419-0421
• [Presentation] 時間制限給餌に伴うグレリンの分泌動態と体温変動について. (2012)
  • Author(s): 佐藤貴弘,中村祐樹,椎村祐樹,御船弘治,寒川賢治,児島将康
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 20120419-0421
• [Presentation] 自然発症高血圧ラットにおける血圧調節とグレリン産生分泌調節の相互作用の障害について. (2012)
  • Author(s): 浜田直和,西芳寛,田尻祐司,瀬戸山健太郎,上村亮三,宮原健吉,塗木徳人,細田洋司,寒川賢治,児島将康,御船弘治
  • Organizer: 第12回日本内分泌学会九州地方会
  • Place of Presentation: 久留米市
  • Year and Date: 2012-08-25
• [Presentation] グレリンによる自律神経機能の調節メカニズムの解明. (2011)
  • Author(s): 御船弘治,佐藤貴弘,寒川賢治,児島将康
  • Organizer: 第29回九州実験動物研究会総会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2011-11-12