2013 Fiscal Year Final Research Report
Neural mechanisms of discrimination of natural sounds learned by guinea pigs in the competition-based training
| Project/Area Number |
22500368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional basic brain science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OJIMA HISAYUKI 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (00104539)
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| Co-Investigator(Kenkyū-buntansha) |
HORIKAWA Junsei 豊橋技術科学大学, 大学院工学研究科情報知能工学, 教授 (50114781)
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| Project Period (FY) |
2010-10-20 – 2014-03-31
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| Keywords | auditory cortex / natural sound / discrimination / classical conditining / voltage-sensitive dye / imaging / positive reinforcement / guinea pigs |
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| Research Abstract |
The current study is to illustrate changes in global activation pattern after conditioning to a natural sound (footstep, F sound). Our assumption is that behavioral achievement would be linked to changes in cortical network. This was revealed in the voltage sensitive dye optical imaging. Competitive training, in which multiple animals were trained together, facilitated animals to reach reward earlier than competitors. Imaging results showed that obvious differences in cortical activation have not been found between naive and trained animals with F sound. The time-reversed F sound, which is spectrally the same as but temporally reversed from F sound, resulted in reduced peak activation, both in naive and trained animals, but in much more reduction in trained animals. These results suggest that the cortical network which may have been dominantly tuned to F sound suppresses activation by its temporally-modified version more efficiently than the corresponding naive network.
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