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2012 Fiscal Year Final Research Report

Neuronal mechanisms for the postnatal development of prosocial behavior

Research Project

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Project/Area Number 22500379
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fusional social brain science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YOKOYAMA Chihiro  独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 研究員 (90264754)

Project Period (FY) 2010 – 2012
Keywords陽電子断層撮影(PET) / コモンマーモセット / 社会的環境 / 社会行動 / セロトニン / 向社会行動
Research Abstract

We developed the tests for evaluating behavior traits constructing interpersonal relationship in non-human primate species, common marmosets, and examined the brain mechanisms underlying them. The positron emission tomography (PET) for in vivo brain imaging in common marmosets suggested the functional role of serotonin in the midline cortical structures as a part of the social and default mode networks.

  • Research Products

    (28 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (19 results) Remarks (1 results)

  • [Journal Article] Evaluation of dopamine D_2/D_3 and serotonin 5-HT_2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography2013

    • Author(s)
      Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H
    • Journal Title

      Psychopharmacol

      Volume: 225 Pages: 329-339

    • Peer Reviewed
  • [Journal Article] The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey2012

    • Author(s)
      Asakawa T, Sugiyama K, Akamine S, Yokoyama C, Shukuri M, Mizuma H, Tsukada H, Onoe H, Namba H
    • Journal Title

      Neurosci Res

      Volume: 74 Pages: 122-128

    • Peer Reviewed
  • [Journal Article] Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets2012

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi T, Onoe H.
    • Journal Title

      Cereb Cortex

      Volume: Epub ahead of print

    • Peer Reviewed
  • [Journal Article] Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease2012

    • Author(s)
      Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N
    • Journal Title

      J Neural Transm

      Volume: 119 Pages: 933-941

    • Peer Reviewed
  • [Journal Article] Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior2011

    • Author(s)
      Watanabe Y, Tsujimura A, Takao K, Nishi K, Ito Y, Yasuhara Y, Nakatomi Y, Yokoyama C, Fukui K, Miyakawa T, Tanaka M
    • Journal Title

      Front Behav Neurosci

      Volume: 5 Pages: 50

    • Peer Reviewed
  • [Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir2011

    • Author(s)
      Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
    • Journal Title

      J Nucl Med

      Volume: 52 Pages: 950-957

    • Peer Reviewed
  • [Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole2011

    • Author(s)
      Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
    • Journal Title

      Neuroreport

      Volume: 22 Pages: 326-330

    • Peer Reviewed
  • [Journal Article] Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys2010

    • Author(s)
      Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H
    • Journal Title

      Synapse

      Volume: 64 Pages: 594-601

    • Peer Reviewed
  • [Presentation] The midline cortical serotonergic system in social behavior traits: Positron emission tomography studies of common marmosets2012

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi K, Onoe H
    • Organizer
      42th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-12
  • [Presentation] 早期養育環境がコモンマーモセットの社会行動へ及ぼす影響2012

    • Author(s)
      横山 ちひろ、川崎 章弘、武田 千穂、尾上 浩隆
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
  • [Presentation] コモンマーモセットにおける音声の個体識別と脳活動の相関2012

    • Author(s)
      加藤 真樹、横山 ちひろ、川崎 章弘、武田 千穂、小池 巧、尾上 浩隆、入來 篤史
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
  • [Presentation] Social behavior traits represented by serotonin function in midline cortical structures2012

    • Author(s)
      Yokoyama C, Kawasaki A, Hayashi K,Onoe H
    • Organizer
      Frontiers in Biomedical Researches on Marmosets as a Primate Model
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-02-21
  • [Presentation] Social behavior and serotonin in the midline cortex: Positron emission tomography studies of common marmosets2012

    • Author(s)
      Yokoyama C
    • Organizer
      14th Conference of Peace through Mind Brain Science
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-02-14
  • [Presentation] Dopamine D2 receptor occupancies of olanzapine and novel antipsychotic lurasidone; study in conscious common marmosets using small-animal positron emission tomography2011

    • Author(s)
      Nakazawa S, Yokoyama C, Nishimura N, Kawasaki A, Kirai S, Doi H, Onoe H
    • Organizer
      41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
  • [Presentation] 他者との社会的関係性の個体差に関わる神経学的要因:コモンマーモセットを用いたPET研究2011

    • Author(s)
      横山ちひろ、川崎章弘、林拓也、尾上浩隆
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
  • [Presentation] マーモセットにおけるボイス刺激を用いたGo-Nogo課題2011

    • Author(s)
      彦坂和雄、難波文恵、横山ちひろ、尾上浩隆
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
  • [Presentation] 脳内アロマテース活性とコモンマーモセットの社会行動特性との関連:11C-cetrozole を用いたPET研究2011

    • Author(s)
      横山ちひろ、川崎章弘、高橋佳代、細谷孝充、渡辺恭良、尾上浩隆
    • Organizer
      第6回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-26
  • [Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング -[11C]AZ10419369を用いたPET研究-2011

    • Author(s)
      山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
    • Organizer
      第6回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-26
  • [Presentation] 無麻酔下コモンマーモセットPETを用いた抗精神病薬ルラシドンとオランザピンのドパミンD2受容体占有率の評価2011

    • Author(s)
      中澤俊介、西村直浩、横山ちひろ、川崎章弘、倉井佐知、土居久志、矢野恒夫、渡辺恭良、尾上浩隆
    • Organizer
      第6回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-26
  • [Presentation] Father's energetic cost during parental care period in cooperatively breeding common marmosets2010

    • Author(s)
      Tatsuta I, Kutsukake N, Yokoyama C, Onoe H, Hasegawa M
    • Organizer
      13th International Behavioral Ecology Congress
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2010-09-30
  • [Presentation] Molecular brain imaging of personality traits in common marmosets2010

    • Author(s)
      Yokoyama C, Onoe H
    • Organizer
      International Primatology Society XXIII Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-13
  • [Presentation] Paternal changes in body weight during parental care period in cooperatively breeding common marmosets2010

    • Author(s)
      Tatsuta I, Kutsukake N, Kawasaki A, Yokoyama C, Onoe H, Hasegawa M
    • Organizer
      International Primatology Society XXIII Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-13
  • [Presentation] Influence of propofol anesthesia on regional functional state of brain serotonin transporter; PET study with [11C]DASB in macaque monkeys2010

    • Author(s)
      Yamanaka H, Onoe K, Yokoyama C, Onoe H
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-10
  • [Presentation] Functional associations of aromatase and serotonin transporters with social behavior: PET study with [11C] cetrozole and [11C] DASB in common marmosets2010

    • Author(s)
      Yokoyama C, Kawasaki A, Takahashi K, Hosoya T, Watanabe Y, Onoe H
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-10
  • [Presentation] Developmental Changes in p-glycoprotein function in the blood-brain barrier of non-human primates: PET study with R-[11C]verapamil2010

    • Author(s)
      Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Katayama Y, Wada Y, Onoe K, Nagata H, Doi H, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-09-09
  • [Presentation] プロポフォール麻酔は[11C]DASBのセロトニントランスポーターへの結合を上昇させる:マカクザルを用いたPET研究2010

    • Author(s)
      山中創、尾上嘉代、横山ちひろ、尾上浩隆
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
  • [Presentation] 社会行動特性と脳内モノアミントランスポーターとの機能的関連:コモンマーモセットを用いたPET研究2010

    • Author(s)
      横山 ちひろ、川崎 章弘、 尾上 嘉代、尾上 浩隆
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-04
  • [Remarks] 理化学研究所ホームページ 広報活動 プレスリリース(2012)

    • URL

      http://www.riken.go.jp/pr/press/2012/20120718/

URL: 

Published: 2014-08-29  

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