2012 Fiscal Year Final Research Report
Indocyanine-green conjugated micelles for cancer theragnosis
| Project/Area Number |
22500406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
MASUMOTO Kazuma 浜松医科大学, 医学部附属病院, 講師 (50464136)
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Yuji 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (10449069)
KATOU Fuminori 浜松医科大学, 医学部, 講師 (60204492)
NAGATA Tetsuji 浜松医科大学, 医学部附属病院, 教授 (60264058)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 光線力学的治療 / 光線力学的診断 / 高分子ミセル / インドシアニングリーン / EPR効果 / 蛍光イメージング |
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| Research Abstract |
We developed an Indocyanine-green conjugated micelles (Lac-ICG) as a novel DDS (drug delivery system)-type photosensitizer that can selectively accumulate in cancer tissues.We examined the usefulness of Lac-ICG in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). 48-72h after administration of Lac-ICG into tumor-bearing mouse models, tumors were clearly distinguished from the surrounded normal tissue on the basis of the Lac-ICG fluorescence. In addition, PDT using Lac-ICG exerted excellent anti-tumor effects.
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