2012 Fiscal Year Final Research Report
Development of quantum dot-based multimodal contrast agents for whole body imaging
| Project/Area Number |
22500407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The Institute of Physical and Chemical Research (2011-2012)
Osaka University (2010) |
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Principal Investigator |
JIN Takashi 独立行政法人理化学研究所, ナノバイオプローブ研究チーム, ナノバイオプローブ研究チーム (80206367)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体イメージング / マルチモーダル造影剤 / 量子ドット / 近赤外蛍光 / MRI / ヒト乳癌 / ヌードマウス |
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| Research Abstract |
The objective of this work was to develop multimodal contrast agents based on near-infrared (NIR) emitting quantum dots for whole body imaging. We could synthesis highly fluorescent near infrared emitting CdSeTe/CdS quantum dots with fluorescence quantum yield of > 50 %. Furthermore, we developed multimodal (NIR/MRI) contrast agents consisting of CdSeTe/CdS quantum dots and Fe_3O_4 nanoparticles and conducted dualmodal imaging of human breast tumors implanted to a nude mouse.
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[Journal Article] Matrix Metalloproteinase-9 Triggers the Gap Junction Impairment and Somatosensory Neuronal Dysfunction in Septic Encephalopathy2013
Author(s)
Huan Wang, Yukio Imamura, Naoya Matsumoto, Nao Yoshikawa, Junichiro Nakagawa, Kazuma Yamakawa, Tomoki Yamada, Yuki Murakami, Satoko Mitani, Takashi Jin, Hiroshi Ogura, Takeshi Shimazu and Akitoshi Seiyama
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Journal Title
Biochem
Volume: Pharmacol.2
Pages: 108
DOI
Peer Reviewed
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