2012 Fiscal Year Final Research Report
The pre-clinical evaluation of animal models of Alzheimer's treatment devices using blood purification
| Project/Area Number |
22500419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGUCHI Nobuya 藤田保健衛生大学, 医療科学部, 教授 (70508077)
NAKAI Sigeru 藤田保健衛生大学, 医療科学部, 教授 (20345896)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
OHASHI Atsushi 藤田保健衛生大学, 医療科学部, 准教授 (30310585)
HORI Hideo 藤田保健衛生大学, 医療科学部, 助教 (00342113)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アルツハイマー病 / 血液浄化 / アミロイドβ蛋白 |
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| Research Abstract |
We intend to develop the extracorporeal system for Alzheimer’s disease by removal of whole blood amyloid beta (Aβ) which may reduce brain Aβ.In this study, we tried toreveal the effect of improving the recognition by extracorporeal system in rats.1. In rat model, the synthetic Aβ that injected into the cisternal was detected inrat whole blood.2. The extracorporeal system for removal Aβ in rats and cognitive evaluation system wasestablished.
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