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2012 Fiscal Year Final Research Report

Automatic selection of the adverse reactions caused by multiple specific drug combinations from laboratory and prescription data observation

Research Project

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Project/Area Number 22500432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionChiba University

Principal Investigator

TAKABAYASHI Katsuhiko  千葉大学, 医学部附属病院, 教授 (90188079)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takahiro  千葉大学, 医学部附属病院, 准教授 (40323422)
Research Collaborator TU Bao・Ho  北陸先端科学技術大学院大学, 知識科学研究科, 教授 (60301199)
土井 俊祐  千葉大学, 医学部附属病院, 客員研究員 (90639072)
Project Period (FY) 2010 – 2012
Keywords薬剤反応性 / 生体生命情報学 / 人口知能 / 危機管理
Research Abstract

We squeezed the adverse reaction cases from the pattern of laboratory data change in admitted patients. Then checked the drugs used before the change and calculated the occurrence related to the adverse reaction cases for each drug. By comparing the occurrence of the cases with expected occurrence rate of the drug combination, we selected the specific combinations. However, they were considered not as the new unknown combination but the bystanders with other drugs, or treated for provocation or therapy. We concluded that each case must be evaluated by human, though computers can choose the high possibility cases .The approach from text mining of discharge summary failed because of many false positive and false negative cases. For example, only 82.9% was described about drug eruption in the diagnosed cases as drug eruption. Thus we need the education of writing discharge summaries as well as the development of syntactic mining.

  • Research Products

    (19 results)

All 2013 2012 2011 2010

All Journal Article (8 results) Presentation (11 results)

  • [Journal Article] Discussion of "Attitude of physicians towards automatic alerting in computerized physician order entry systems"2013

    • Author(s)
      Bates DW, Baysari MT, Dugas M, Haefeli WE, Kushniruk AW, Lehmann CU, Liu J, Mantas J, Margolis A, Miyo K, Nohr C, Peleg M, de Quiros FG, Slight SP, Starmer J, Takabayashi K, Westbrook JI
    • Journal Title

      Methods Inf Med

      Volume: 52 Pages: 109-27

  • [Journal Article] 医療の最先端内科学における医療情報学の応用2012

    • Author(s)
      高林克日己
    • Journal Title

      日本内科学会雑誌

      Volume: 10;101 Pages: 3239-46

  • [Journal Article] Data analysis and data mining: current issues in biomedical informatics2011

    • Author(s)
      Bellazzi R, Diomidous M, Sarkar IN,Takabayashi K, Ziegler A, McCray AT
    • Journal Title

      Methods Inf Med

      Volume: 50 Pages: 536-44

  • [Journal Article] Japanese EMRs and IT in Medicine2011

    • Author(s)
      Takabayashi K, Doi S, Suzuki T
    • Journal Title

      Healthc Inform Res

      Volume: 17 Pages: 178-83

  • [Journal Article] 藤田伸輔高齢社会における在宅医療センター構想2011

    • Author(s)
      高林克日己
    • Journal Title

      癌と化学療法

      Volume: 1 Pages: 14-6

  • [Journal Article] 退院時サマリーと検査結果のマッチングによる薬剤副作用情報の解析2011

    • Author(s)
      鈴木隆弘,十時章,土井俊祐,木村隆,高林克日己
    • Journal Title

      第31回日本医療情報学会抄録集

      Pages: 752-753

  • [Journal Article] EMR systems and secondary use for the retrieval of similar case reports2010

    • Author(s)
      Takabayashi K
    • Journal Title

      GMDS-Jahrestagung

      Volume: 55 Pages: 43

  • [Journal Article] 副作用の発症と強く関連する薬剤併用例の抽出2010

    • Author(s)
      十時章,鈴木隆弘,田村俊世,高林克日己
    • Journal Title

      第31回医療情報学連合大会論文集

      Pages: 291-292

  • [Presentation] 電子化診療録二次利用のための診療録教育の重要性日本医学教育学会2013

    • Author(s)
      高林克日己 鈴木隆弘 田辺政裕
    • Year and Date
      20130000
  • [Presentation] 電子カルテの記載による薬剤副作用情報の解析2013

    • Author(s)
      鈴木隆弘 土井俊祐 木村隆 高林克日己
    • Organizer
      平成24年度医療情報マネージメント部門連絡会議
    • Year and Date
      20130000
  • [Presentation] Ways to analyze Hospital performance using hospital routine data2013

    • Author(s)
      Takabayashi K
    • Organizer
      EFMI (European Federation of MedicalInformatics) 2013
    • Place of Presentation
      Prague
    • Year and Date
      20130000
  • [Presentation] Progress of Medical Informatics in the hospital2013

    • Author(s)
      Takabayashi K
    • Organizer
      Memorial Symposium in Braunschweig
    • Year and Date
      20130000
  • [Presentation] Text mining for adverse reactions from EMR2013

    • Author(s)
      Suzuki T
    • Organizer
      German Japanese Medical Informatics (Text Mining)
    • Place of Presentation
      Symposium Chiba
    • Year and Date
      20130000
  • [Presentation] Japanese EMR and IT in Medicine APACHPC Seoul2011

    • Author(s)
      Takabayashi K, Doi S, Suzuki T
    • Year and Date
      20110000
  • [Presentation] 看護記録、医師の立場から:電子カルテ時代に求められる看護記録とは?2011

    • Author(s)
      高林克日己
    • Organizer
      第31回日本医療情報学会
    • Year and Date
      20110000
  • [Presentation] 退院時サマリーと検査結果のマッチングによる薬剤副作用情報の解析2011

    • Author(s)
      鈴木隆弘,十時章,土井俊祐,木村隆,高林克日己
    • Organizer
      第31回日本医療情報学会
    • Year and Date
      20110000
  • [Presentation] 副作用の発症と強く関連する薬剤併用例の抽出2010

    • Author(s)
      十時章,鈴木隆弘,田村俊世,高林克日己
    • Organizer
      第30回医療情報学連合大会
    • Year and Date
      20100000
  • [Presentation] Similar Case Report Retrieval by Text Mining Technique2010

    • Author(s)
      Takabayashi K
    • Organizer
      Keynote Speech in GMDS(Annual Meeting of German Society of Medical Informatics)
    • Place of Presentation
      Manheim
    • Year and Date
      20100000
  • [Presentation] Extraction of the medication closely relates to liver dysfunction in MEDINFO2010

    • Author(s)
      Akira Totoki, Suzuki Takahiroa, Toshiyo Tamura, Katsuhiko Takabayashi
    • Organizer
      Cape Town
    • Year and Date
      20100000

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Published: 2014-08-29  

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