2012 Fiscal Year Final Research Report
A preliminary study for reduction of anthracycline-induced cardiotocixity by regulation of p53 and mTOR in myocardium using ultrasound
| Project/Area Number |
22500439
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical systems
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
MIZUNO Reiko 奈良県立医科大学, 医学部, 講師 (80398437)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIMOTO Shinichi 奈良県立医科大学, 医学部, 教授 (70209097)
KANNO Masatoshi 奈良県立医科大学, 医学部, 教授 (30195185)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 超音波医科学 |
|---|
| Research Abstract |
We investigated whether the cardioprotective effects of edaravone and pifithrin were increased with ultrasound exposure. In addition, clinical research about early detection of anthracycline-induced cardiotoxicity was performed using left ventricular end-systolic wall stress-velocity of circumferential fiber shortening relationship (WS-Vcf relationship). Significant enhancement of the cardioprotective effects of these agents with ultrasound exposure was not seen. We plan the further investigation about the condition of ultrasound exposure. In the clinical research, WS-Vcf relationship was useful for the detection of the early anthracycline-induced cardiotoxicity.
|
