2012 Fiscal Year Final Research Report
Point-of-care testing devices with original microfluidic technology and signal amplification method
| Project/Area Number |
22500448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HOSOKAWA Kazuo 独立行政法人理化学研究所, 前田バイオ工学研究室, 専任研究員 (00373366)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マイクロチップ / イムノアッセイ / ポイント・オブ・ケア / 疾患マーカー / 臨床検査 / 抗体 |
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| Research Abstract |
We have developed rapid and sensitive detection methods for disease biomarkers using original microchip and amplification technologies. First, we found that covalent immobilization of antibody to the substrate via dextran matrix is advantageous in terms of sensitivity. Next, we succeeded in detecting three biomarker proteins simultaneously on the microchip. Finally, this method was successfully applied to microRNA detection as well.
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