2012 Fiscal Year Final Research Report
Mechanotransduction in Rat Chondrocytes
| Project/Area Number |
22500457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
IMAI Shinji 滋賀医科大学, 医学部, 准教授 (90283556)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSUE Yoshitaka 滋賀医科大学, 医学部, 教授 (30209548)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 軟骨細胞 / 力学的刺激 / 細胞間応答 / サイトカイン / 器質産生能 |
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| Research Abstract |
We first confirmed rapid up-regulation of the putative chondro-protective cytokine, interleukin (IL)-4, as an immediate response to MS. We then studied the role of IL-4 by investigating responses to exogenous IL-4 or a specific IL-4 inhibitor, combined with MS. Next we investigated the intracellular second messengers. Since chondrocyte phenotype alters according to the extracellular environment, we characterized the response to mechanotransduction in 3-dimensionally embedded chondrocytes. Expression of aggrecan and type II collagen was significantly up-regulated by exogenous IL-4 whereas MS-induced matrix synthesis was inhibited by an IL-4 blocker. Further, MS-induced matrix synthesis was completely blocked by a p38 MAPK inhibitor.
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Research Products
(46 results)
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[Journal Article] Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve2012
Author(s)
Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y
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Journal Title
Plos ONE
Volume: 7(9)
Pages: e44592
Peer Reviewed
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[Presentation] Clinical benefit of a Japanese convalescent rehabilitation ward on patients with rheumatoid arthritis is not only recovery of ADL, but also improvement of QOL2010
Author(s)
Kikuchi K, Imai S, Kawasaki T, Saruhashi Y, Mori K, Isoya E, Okumura N, Kodama N, Kubo M, Mimura T, Yamaoka H, Matsusue Y
Organizer
14th Congress of Asia Pacific League of Associations for Rheumatology
Place of Presentation
Hong Kong
Year and Date
20100711-15
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