2012 Fiscal Year Final Research Report
Investigation of neurochemical mechanism for the effect of trans-cranial direct current stimulation using multi-modal neuroimaging techniques
| Project/Area Number |
22500479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | リハビリテーション医学 |
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| Research Abstract |
we aimed to investigate the neurochemical mechanism for the effect of trans-cranial Direct Current Stimulation (t-DCS) using f-NIRS (functional near-infrared spectroscopy) combined with functional Magnetic Resonance Imaging (f-MRI) and Positron Emission Tomography (PET). We confirmed that the upper limb representation in primary motor area, referred to the international 10/20 system for EEG electrode placement, matched well with the motor map derived from f-MRI. Also, f-NIRS results demonstrated that the increase of [oxy-Hb] during a motor task (repetitive grip and release) was enhanced by anodal t-DCS effect, but after exposure to sulpiride, a dopamine D2 antagonist, the enhancement was interfered. The fact may suggest that the effect of t-DCS could be modulated by dopamine system. The findings might contribute to the improvement of t-DCS effect, in terms of its augmentation and persistency.
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[Journal Article] Preparation of acute living hippocampal slice from commonmarmoset (Callithrix jacchus) for synaptic function analysis2012
Author(s)
Oh-Nishi, A. , Obayashi, S., T.Minamimoto, Y., Nagai, Y., Hori, T., Suhara
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Journal Title
Neuroscience Research
Volume: 72(3)
Pages: 275-278
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