Exercise therapy for hypertension and diabetes mellitus: involvement of cross-adaptation to stress via inhibition of sympathetic nervous system

2012 Fiscal Year Final Research Report

• Project/Area Number: 22500609
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Tottori University
• Principal Investigator: MIYOSHI Michio 鳥取大学, 医学部, 助教 (20093627)
• Co-Investigator(Kenkyū-buntansha): WATANABE Tatsuo 鳥取大学, 医学部, 教授 (60182929) ; KOBA Satoshi 鳥取大学, 医学部, 講師 (40565743)
• Project Period (FY): 2010 – 2012
• Keywords: 運動とトレーニング

Research Abstract

We investigated effects of 4-weeks’ running training on the increases in blood pressure (BP) and catecholamine levels induced by a novel stress (immobilization stress) in spontaneously hypertensive rats (SHR). The rats’ sensitivity to exogenously infused norepinephrine (NE) was investigated too. The present results suggest that the stress-induced activation of the sympathetic nervous system and the sensitivity to NE were each attenuated after 4-weeks’ running training, with a consequent reduction in the BP response to a novel stress.

Research Products

• [Journal Article] Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II. American Journal of Physiology (2013)
  • Author(s): Koba, S., Watanabe, R., Kano, N. and Watanabe, T
  • Journal Title: Heart and Circulatory Physiology Volume: 304 Pages: H142-H153
  • DOI: DOI:10.1152/ajpheart.00423.2012
  • Peer Reviewed
• [Journal Article] Exercise pressor reflex function in female rats fluctuates with the estrous cycle. (2012)
  • Author(s): Koba, S., Yoshinaga, K., Fujita, S., Miyoshi, M. and Watanabe, T.
  • Journal Title: Journal of Applied Physiology Volume: 113(5) Pages: 719-726
  • DOI: DOI:10.1152/japplphysiol.00396.2012
  • Peer Reviewed
• [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans (2012)
  • Author(s): Fukada, M., Kano, E., Miyoshi, M., Komaki, R. and Watanabe, T.
  • Journal Title: Chemical Senses Volume: 37(4) Pages: 347-356
  • DOI: DOI:10.1093/chemse/bjr108
  • Peer Reviewed
• [Journal Article] Green odor and depressive-like state in rats: Toward an evidence-based alternative medicine? (2011)
  • Author(s): Watanabe, T., Fujihara, M., Murakami, E., Miyoshi, M., Tanaka, Y., Koba, S. andTachibana, H.
  • Journal Title: Behavioural Brain Res Volume: 224(2) Pages: 290-296
  • DOI: DOI:10.1016/j.bbr.2011.06.001.
  • Peer Reviewed
• [Journal Article] Protective effects of ginger against aspirin-induced gastric ulcers in rats. (2011)
  • Author(s): Wang, Z., Hasegawa, J., Wang, X.,Matsuda, A., Tokuda, T., Miura, N. and Watanabe, T.
  • Journal Title: Yonago Acta medica Volume: 54 Pages: 11-19
  • URL: http:lib.med.tottori-u.ac.jp/yam/yam54-1/54_011-0
  • Peer Reviewed
• [Journal Article] Chronic restraint stress in rats suppresses sweet and umami taste responses and lingual expression of T1R3 mRNA (2010)
  • Author(s): Okamoto, A., Miyoshi, M., Imoto, T., Ryoke, K., and Watanabe, T.
  • Journal Title: Neuroscience Letters Volume: 486(3) Pages: 211-214
  • DOI: DOI:10.1016/j.neulet.2010.09.055.
  • Peer Reviewed
• [Journal Article] Green odor inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring (2010)
  • Author(s): Fujita, S., Ueki, S., Miyoshi, M., and Watanabe, T.
  • Journal Title: Hormones and Behav Volume: 58(2) Pages: 264-272
  • DOI: DOI:10.1016/j.yhbeh.2010.03.007.ior
  • Peer Reviewed
• [Journal Article] Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats. (2010)
  • Author(s): Miyoshi, M. and Watanabe, T.
  • Journal Title: European Journal of Applied Physiology Volume: 109(1) Pages: 49-57
  • DOI: DOI:10.1007/s00421-009-1157-8
  • Peer Reviewed
• [Presentation] 活動筋反射:運動骨格筋による交感神経刺激のメカニズム (2013)
  • Author(s): 木場 智史
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2013-03-28
• [Presentation] バラの香りを吸入するとストレスによる皮膚バリア障害が抑制される ～ラットとヒトを用いた検討～ (2013)
  • Author(s): 弓岡 英里、深田 美香、渡邊達生
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2013-03-27
• [Presentation] 心筋梗塞ラットの運動トレーニングは中枢性交感神経賦活応答を抑制する (2012)
  • Author(s): 木場 智史、井上 裕美子、久留 一郎、渡邊 達生
  • Organizer: 第64回日本生理学会中国四国地方会
  • Place of Presentation: 高知
  • Year and Date: 2012-10-28
• [Presentation] うつ病に対する緑の香りの予防・治療効果について ～ラットを用いた検討～ (2012)
  • Author(s): 渡邊達生
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-29
• [Presentation] 緑の香りはラットのうつ病様状態を緩和する (2011)
  • Author(s): 橘広人、渡邊達生
  • Organizer: 第50回日本生気象学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-11-05
• [Presentation] アンジオテンシンII由来高血圧ラットの活動筋反射は活性酸素によって増強される (2011)
  • Author(s): 木場智史、渡辺亮介、狩野尚香、渡邊達生
  • Organizer: 第63回日本生理学会中国四国地方会
  • Place of Presentation: 広島
  • Year and Date: 2011-10-23
• [Presentation] 性周期は活動筋反射に影響する (2010)
  • Author(s): 木場智史、吉永健嗣、藤田小矢香、渡邊達生
  • Organizer: 第62回日本生理学会中国四国地方会
  • Place of Presentation: 出雲
  • Year and Date: 2010-11-20
• [Presentation] 発熱とアンジオテンシンII ～炎症性サイトカイン産生促進作用について～ (2010)
  • Author(s): 渡邊達生
  • Organizer: 日本麻酔学会中国・四国支部第47回学術集会
  • Place of Presentation: 米子
  • Year and Date: 2010-09-11
• [Presentation] 妊娠ラットの香料吸入で胎生期ストレスによる仔の内分泌・行動異常を抑制できるか? (2010)
  • Author(s): 藤田小矢香、上木史織、三好美智夫、渡邊達生
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Remarks]
  • URL: http://www.med.tottori-u.ac.jp/intgphys/6005.html