2012 Fiscal Year Final Research Report
Antidepressant and anxiolytic effects of physical exercise and brain plasticity
| Project/Area Number |
22500612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
KITA Ichiro 首都大学東京, 人間健康科学研究科, 教授 (10186223)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 行動神経科学 / 運動 / ストレス / うつ病 / 脳機能 / 免疫組織化学 |
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| Research Abstract |
A great number of studies have suggested that physical exercise can reduce the incidence and symptoms of stress-related psychiatric disorders such as depression and anxiety through exercise-induced neuroplasticity, but the underlying neural mechanisms are not yet fully understood. In the present study, we examined how physical exercise mediates the stress-related psychiatric disorders, and considered the exercise parameters that result in the most favorable changes in brain plasticity. The results of this study suggested that physical exercise with less stress, such as mild or voluntary exercise, may be most efficient for preventing the incidence of stress-related psychiatric disorders.
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[Journal Article] Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS.2010
Author(s)
Nishijima T, Piriz J, Duflot S, Fernandez AM, Gaitan G, Gomez-Pinedo U, Garcia Verdugo JM, Leroy F, Soya H, Nunes A, Torres-Aleman I.
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Journal Title
Neuron
Volume: 67
Pages: 834-846
Peer Reviewed
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